Research Article Sub-Acute 28-Days Oral Toxicity Study of Deltamethrin on Female Rats and the Protective Role of Moringa Tea

摘要

Background and Objective: Pyrethroid insecticides are extensively used in agriculture and public health sectors to control insects. It accumulates in fatty tissues, food and environment and caused several adverse effects to mammals and ecosystem. The current research was designed to study the sub-acute oral toxicity "28 days" of deltamethrin (DLM) on female rats and to evaluate the protective effect of moringa tea. Materials and Methods: Rats were divided into four groups of five rats each, control group, moringa tea group, deltamethrin group and deltamethrin-moringa tea group. After 28 days of exposure, serum and tissues samples were used for biochemical and histopathological investigations. All data were analyzed using one-way analysis of variance (ANOVA) followed by post hoc multiple comparisons. Results: Deltamethrin-induced significant alterations in the liver dysfunction biomarkers such as AST (aspartate aminotransferase), ALT (alanine aminotransferase) and ALP (alkaline phosphatase) in the serum of female rats. It caused also, significant changes in oxidative stress markers such as lipid peroxidation (LPO), glutathione (GSH) and catalase (CAT) and histological alteration in the liver tissues of treated female rats. Deltamethrin induced a significant reduction (p<0.05) in body weights and relative liver weights compared to untreated female rats. Co-administration of moringa tea to deltamethrin-intoxicated female rats improved liver functions and restored the liver and oxidative stress biomarkers to within normal ringing. Conclusion: DLM-induced oxidative stress, lipid peroxidation and liver damage in female rats. Administration of moringa tea could prevent the adverse and toxic effects of pyrethroid insecticides. Moringa tea may be useful, easy and economical to protect human against the adverse toxic effects of pesticides exposure, especially of agriculture workers.