Organofluorine Chemistry: Deoxyfluorination Reagents for C-F Bond Synthesis

摘要

The influence of the C-F bond on the conformation of organic molecules is outlined. Strategies for incorporating the C-F bond into molecular frameworks by deoxyfluorination reactions are summarized with a particular focus on recent and emerging fluorination reagents. The syntheses of individual stereoisomers of straight-chain alkanes carrying up to six consecutive C-F bonds is presented to illustrate the power of the deoxyfluorination approach in controlling the introduction of the C-F bond at a stereogenic center.