Diagnosis and management of inherited von Willebrand disease in the next decade: a clinical perspective

摘要

Von Willebrand disease (VWD) is the most common type of inherited bleeding disorder and occurs in approximately 1% of the general population. It is caused by qualitative or quantitative deficiencies in von Willebrand factor (VWF), which results in an increased risk of bleeding. The clinical manifestations of VWD vary widely from patient to patient, reflecting the many different underlying mechanisms that can produce low levels of VWF or defective VWF. Treatment options generally include desmopressin or replacement therapy with VWF-containing factor VIII concentrates. The articles in this supplement highlight some of the key issues currently surrounding the management of patients with VWD, and look to the future to see how patient care may advance in the coming years.