Short Communication:Increase of HIV-1 K103N Transmitted Drug Resistance and Its Association with Efavirenz Use in South Korea

摘要

Previous studies reported a relatively low prevalence of transmitted drug resistance (TDR) in South Korea(<5%). A genotypic resistance test was performed on 131 treatment-naive HIV-1-infected individuals fromFebruary 2013 to February 2014. Eleven individuals (8.4%) presented TDR, of whom eight had K103N,revealing a significant increase in K103N TDR compared to previous studies (p< 0.001). Using phylogeneticanalysis, we identified three distinct clustering pairs with genetic relativeness and a total of five independentstrains among the eight K103N cases. Our findings suggest that multiple sources of K103N occurred, mostlikely as a consequence of increased efavirenz use in South Korea.