• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The lancet. Respiratory medicine. >Efficacy, safety, and biomarker analysis of ensartinib in crizotinib-resistant, ALK-positive non-small-cell lung cancer: a multicentre, phase 2 trial
【24h】

Efficacy, safety, and biomarker analysis of ensartinib in crizotinib-resistant, ALK-positive non-small-cell lung cancer: a multicentre, phase 2 trial

机译：菌根抗性，ALK阳性非小细胞肺癌中的疗效，安全性和生物标志物分析：多期，第2期试验

获取原文
获取原文并翻译 | 示例
获取外文期刊封面目录资料
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background Ensartinib is a potent new-generation ALK inhibitor with high activity against a broad range of known crizotinib-resistant ALK mutations and CNS metastases. We aimed to assess the efficacy and safety of ensartinib in ALK-positive patients with non-small-cell lung cancer (NSCLC), in whom crizotinib therapy was unsuccessful. The associations between ensartinib efficacy and crizotinib-resistant mutations were also explored.
机译：背景技术念珠菌是一种有效的新一代ALK抑制剂，其具有高活性，抗广泛的已知的屈曲抗性ALK突变和CNS转移。 我们的旨在评估酶的非小细胞肺癌（NSCLC）的ALK阳性患者的疗效和安全性，其中CRIZOTINIB治疗不成功。 还探讨了念珠菌疗效和抗序突变突变之间的关联。

著录项

  • 来源
    《The lancet. Respiratory medicine.》 |2020年第1期|共9页
  • 作者

    Yang Yunpeng; Zhou Jianya; Zhou Jianying; Feng Jifeng; Zhuang Wu; Chen Jianhua; Zhao Jun; Zhong Wei; Zhao Yanqiu; Zhang Yiping; Song Yong; Hu Yi; Yu Zhuang; Gong Youling; Chen Yuan; Ye Feng; Zhang Shucai; Cao Lejie; Fan Yun; Wu Gang; Guo Yubiao; Zhou Chengzhi; Ma Kewei; Fang Jian; Feng Weineng; Liu Yunpeng; Zheng Zhendong; Li Gaofeng; Wu Ning; Song Wei; Liu Xiaoqing; Zhao Shijun; Ding Lieming; Mao Li; Selvaggi Giovanni; Yuan Xiaobin; Fu Yuanqing; Wang Tao; Xiao Shanshan; Zhang Li;

  • 作者单位

    Sun Yat Sen Univ Collaborat Innovat Ctr Canc Med Dept Med Oncol State Key Lab Oncol South China;

    Zhejiang Univ Affiliated Hosp 1 Coll Med Dept Resp Dis Thorac Dis Ctr Hangzhou Zhejiang;

    Zhejiang Univ Affiliated Hosp 1 Coll Med Dept Resp Dis Thorac Dis Ctr Hangzhou Zhejiang;

    Nanjing Med Univ Jiangsu Canc Hosp Jiangsu Inst Canc Res Dept Med Oncol Affiliated Canc Hosp;

    Fujian Med Univ Fujian Prov Canc Hosp Dept Thorac Oncol Canc Hosp Fuzhou Fujian Peoples R;

    Hunan Canc Hosp Dept Med Oncol Chest Changsha Hunan Peoples R China;

    Beijing Canc Hosp Dept Thorac Oncol Beijing Peoples R China;

    Chinese Acad Med Sci Peking Union Med Coll Hosp Peking Union Med Coll Dept Pulm Med Beijing;

    Zhengzhou Univ Henan Prov Canc Hosp Resp Dept Internal Med Affiliated Canc Hosp Zhengzhou;

    Zhejiang Canc Hosp Thorac Med Oncol Hangzhou Zhejiang Peoples R China;

    Nanjing Univ Jinling Hosp Div Resp Med Sch Med Nanjing Jiangsu Peoples R China;

    Chinese Peoples Liberat Army Gen Hosp Dept Oncol Beijing Peoples R China;

    Qingdao Univ Dept Oncol Affiliated Hosp Qingdao Shandong Peoples R China;

    Sichuan Univ West China Hosp Canc Ctr Dept Thorac Oncol Chengdu Sichuan Peoples R China;

    Huazhong Univ Sci &

    Technol Tongji Hosp Tongji Med Coll Dept Oncol Wuhan Hubei Peoples R China;

    Xiamen Univ Affiliated Hosp 1 Fujian Med Univ Sch Med Dept Med Oncol Canc Hosp Teaching Hosp;

    Capital Med Univ Beijing Chest Hosp Beijing TB &

    Thorac Tumor Res Inst Dept Med Oncol Beijing;

    Univ Sci &

    Technol China Anhui Prov Hosp Resp Med Affiliated Hosp 1 Hefei Anhui Peoples R;

    Zhejiang Canc Hosp Thorac Med Oncol Hangzhou Zhejiang Peoples R China;

    Huazhong Univ Sci &

    Technol Union Hosp Tongji Med Coll Canc Ctr Wuhan Hubei Peoples R China;

    Sun Yat Sen Univ Affiliated Hosp 1 Pulm &

    Crit Care Med Guangzhou Guangdong Peoples R China;

    Guangzhou Med Univ Natl Clin Res Ctr Resp Dis Guangzhou Inst Resp Hlth Resp Med Dept Affiliated;

    First Hosp Jilin Univ Canc Ctr Changchun Jilin Peoples R China;

    Beijing Canc Hosp Dept Thorac Oncol Beijing Peoples R China;

    First Peoples Hosp Foshan Dept Head &

    Neck &

    Thorac Med Oncol Foshan Peoples R China;

    China Med Univ Oncol Med Hosp 1 Shenyang Liaoning Peoples R China;

    Gen Hosp Northern Theater Command Oncol Dept Shenyang Liaoning Peoples R China;

    Yunnan Canc Hosp Dept Thorac Surg 2 Kunming Yunnan Peoples R China;

    Chinese Acad Med Sci Dept Diagnost Radiol Peking Union Med Coll Natl Canc Ctr Canc Hosp Natl;

    Chinese Acad Med Sci Peking Union Med Coll Hosp Peking Union Med Coll Dept Radiol Beijing;

    Chinese Peoples Liberat Army Gen Hosp Dept Pulm Oncol Med Ctr 5 Beijing Peoples R China;

    Chinese Acad Med Sci Dept Diagnost Radiol Peking Union Med Coll Natl Canc Ctr Canc Hosp Natl;

    Betta Pharmaceut Hangzhou Zhejiang Peoples R China;

    Betta Pharmaceut Hangzhou Zhejiang Peoples R China;

    X Covery Holdings Palm Beach Gardens FL USA;

    Betta Pharmaceut Hangzhou Zhejiang Peoples R China;

    Betta Pharmaceut Hangzhou Zhejiang Peoples R China;

    Hangzhou Repugene Technol Hangzhou Zhejiang Peoples R China;

    Hangzhou Repugene Technol Hangzhou Zhejiang Peoples R China;

    Sun Yat Sen Univ Collaborat Innovat Ctr Canc Med Dept Med Oncol State Key Lab Oncol South China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 呼吸系及胸部疾病;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号