Safety, reactogenicity, and immunogenicity of a chimpanzee adenovirus vectored Ebola vaccine in adults in Africa: a randomised, observer-blind, placebo-controlled, phase 2 trial

Tapia Milagritos D.; Sow Samba O.; Ndiaye Birahim P.; Mbaye Khardiata D.; Thiongane Aliou; Ndour Cheikh T.; Mboup Souleymane; Ake Julie A.; Keshinro Babajide; Akintunde Gideon A.; Kinge Thompson N.; Vernet Guy; Bigna Jean Joel; Oguche Stephen; Koram Kwadwo A.; Asante Kwaku P.; Hogrefe Wayne R.; Guenther Stephan; Naficy Abdi; De Ryck Iris; Debois Muriel; Bourguignon Patricia; Jongert Erik; Ballou William R.; Koutsoukos Marguerite; Roman Francois

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Safety, reactogenicity, and immunogenicity of a chimpanzee adenovirus vectored Ebola vaccine in adults in Africa: a randomised, observer-blind, placebo-controlled, phase 2 trial

机译：Chimpanzee腺病毒的安全性，反应性和免疫原性，在非洲成人中的埃博拉疫苗：随机，观察者盲，安慰剂控制，第2期试验

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Background: The 2014 Zaire Ebola virus disease epidemic accelerated vaccine development for the virus. We aimed to assess the safety, reactogenicity, and immunogenicity of one dose of monovalent, recombinant, chimpanzee adenovirus type-3 vectored Zaire Ebola glycoprotein vaccine (ChAd3-EBO-Z) in adults.

机译：背景：2014年扎伊尔埃博拉病毒疾病流行病病毒的疫苗发育。我们旨在评估一剂单价，重组，黑猩猩腺病毒型-3的安全性，反应源性和免疫原性，其在成人中的Zaire Ebola糖蛋白疫苗（ChAd3-EBO-Z）。

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《The Lancet infectious diseases》 |2020年第6期|共12页
作者
Tapia Milagritos D.; Sow Samba O.; Ndiaye Birahim P.; Mbaye Khardiata D.; Thiongane Aliou; Ndour Cheikh T.; Mboup Souleymane; Ake Julie A.; Keshinro Babajide; Akintunde Gideon A.; Kinge Thompson N.; Vernet Guy; Bigna Jean Joel; Oguche Stephen; Koram Kwadwo A.; Asante Kwaku P.; Hogrefe Wayne R.; Guenther Stephan; Naficy Abdi; De Ryck Iris; Debois Muriel; Bourguignon Patricia; Jongert Erik; Ballou William R.; Koutsoukos Marguerite; Roman Francois;
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作者单位

Univ Maryland Ctr Vaccine Dev Sch Med Baltimore MD 21093 USA;

Ctr Dev Vaccins Bamako Mali;

Le Dantec Lab Bacteriol &

Virol Dakar Senegal;

Univ Cheikh Anta Diop Dakar Senegal;

Univ Cheikh Anta Diop Dakar Senegal;

Univ Cheikh Anta Diop Dakar Senegal;

Le Dantec Lab Bacteriol &

Virol Dakar Senegal;

Walter Reed Army Inst Res Mil HIV Res Program Silver Spring MD USA;

Walter Reed Program Abuja Nigeria;

Walter Reed Program Abuja Nigeria;

Bamenda Reg Hosp Bamenda Cameroon;

Ctr Pasteur Cameroun Yaounde Cameroon;

Ctr Pasteur Cameroun Yaounde Cameroon;

Univ Jos &

Jos Univ Teaching Hosp Jos Nigeria;

Univ Ghana Noguchi Mem Inst Med Res Legon Accra Ghana;

Kintampo Hlth Res Ctr Kintampo Ghana;

Q2 Solut San Juan Capistrano CA USA;

Bernhard Nocht Inst Trop Med Hamburg Germany;

Quintiles La Defense France;

GSK Wavre Belgium;

GSK Wavre Belgium;

GSK Wavre Belgium;

GSK Wavre Belgium;

GSK Rockville MD USA;

GSK Wavre Belgium;

GSK Wavre Belgium;

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正文语种 eng
中图分类传染病;
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1. Safety, reactogenicity, and immunogenicity of a chimpanzee adenovirus vectored Ebola vaccine in adults in Africa: a randomised, observer-blind, placebo-controlled, phase 2 trial [J] . Tapia Milagritos D., Sow Samba O., Ndiaye Birahim P., The Lancet infectious diseases . 2020,第6期

机译：Chimpanzee腺病毒的安全性，反应性和免疫原性，在非洲成人中的埃博拉疫苗：随机，观察者盲，安慰剂控制，第2期试验
2. Safety and immunogenicity of a chimpanzee adenovirus-vectored Ebola vaccine in healthy adults: a randomised, double-blind, placebo-controlled, dose-finding, phase 1/2a study [J] . De Santis Olga, Audran Regine, Pothin Emilie, The Lancet infectious diseases . 2016,第3期

机译：黑猩猩腺病毒载体埃博拉疫苗在健康成年人中的安全性和免疫原性：一项随机，双盲，安慰剂对照，剂量寻找，1 / 2a期研究
3. Safety and immunogenicity of a recombinant adenovirus type-5 vector-based Ebola vaccine in healthy adults in Sierra Leone: a single-centre, randomised, double-blind, placebo-controlled, phase 2 trial [J] . Zhu Feng-Cai, Wurie Alie H., Hou Li-Hua, The Lancet . 2017,第10069期

机译：在塞拉利昂健康成人中重组腺病毒基于载体的埃博拉疫苗的安全性和免疫原性：单中心，随机，双盲，安慰剂控制，第2期试验
4. A double-blind, randomized phase II trial of thesafety and immunogenicity of 26-valent group A streptococcus vaccine in healthy adults [C] . Shelly A. McNeil, Scott A. Halperin, Joanne M. Langley, Lancefield International Symposium on Streptococci and Streptococcal Diseases . 2006

机译：一种双盲，随机期II试验，对健康成人的26岁的26岁群体的疫苗疫苗
5. Uncovering the Mechanisms Underlying the Immunogenicity of Adenovirus Vaccine Vectors [D] . Nidetz, Natalie Frances. 2018

机译：揭示腺病毒疫苗载体免疫原性的机制
6. Immunogenicity and safety of a tetravalent dengue vaccine in healthy adults in India: A randomized observer-blind placebo-controlled phase II trial [O] . Anand Prakash Dubey, Sharad Agarkhedkar, Jugesh Chhatwal, 2016

机译：四价登革热疫苗在印度健康成年人中的免疫原性和安全性：一项随机观察者盲安慰剂对照的II期临床试验
7. Safety, reactogenicity, and immunogenicity of a chimpanzee adenovirus vectored Ebola vaccine in adults in Africa: a randomised, observer-blind, placebo-controlled, phase 2 trial [O] . Milagritos D Tapia, Samba O Sow, Birahim P Ndiaye, 2020

机译：黑猩猩腺病毒的安全，反应性和免疫原性，在非洲成人中的埃博拉疫苗：随机，观察者 - 盲，安慰剂控制，第2期试验

Safety, reactogenicity, and immunogenicity of a chimpanzee adenovirus vectored Ebola vaccine in adults in Africa: a randomised, observer-blind, placebo-controlled, phase 2 trial

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