Cadazolid for the treatment of Clostridium difficile infection: results of two double-blind, placebo-controlled, non-inferiority, randomised phase 3 trials

Gerding Dale N.; Cornely Oliver A.; Grill Simon; Kracker Hilke; Marrast Anne Claire; Nord Carl Erik; Talbot George H.; Buitrago Martha; Diaconescu Iulian Gheorghe; de Oliveira Claudia Murta; Preotescu Liliana; Pullman John; Louie Thomas J.; Wilcox Mark H.

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Cadazolid for the treatment of Clostridium difficile infection: results of two double-blind, placebo-controlled, non-inferiority, randomised phase 3 trials

机译：菌唑胺用于治疗梭菌性艰难感染：两次双盲，安慰剂控制，非劣质性的结果，随机相3试验

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Background Cadazolid is a novel quinoxolidinone antibiotic developed for treating Clostridium difficile infection. We aimed to investigate the safety and efficacy of cadazolid compared with vancomycin in patients with C difficile infection.

机译：背景Cadazolid是一种用于治疗梭菌性艰难梭菌感染的新型喹喔啉酮抗生素。我们的旨在探讨Cadazolid与C Termicile感染患者的万古霉素相比的安全性和疗效。

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来源
《The Lancet infectious diseases》 |2019年第3期|共10页
作者
Gerding Dale N.; Cornely Oliver A.; Grill Simon; Kracker Hilke; Marrast Anne Claire; Nord Carl Erik; Talbot George H.; Buitrago Martha; Diaconescu Iulian Gheorghe; de Oliveira Claudia Murta; Preotescu Liliana; Pullman John; Louie Thomas J.; Wilcox Mark H.;
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Edward Hines Jr VA Hosp Hines IL 60141 USA;

Univ Cologne Dept Internal Med Cologne Excellence Cluster Cellular Stress Respon Clin Trials Ctr;

Actelion Pharmaceut Allschwil Switzerland;

Actelion Pharmaceut Allschwil Switzerland;

Actelion Pharmaceut Allschwil Switzerland;

Karolinska Inst Karolinska Univ Hosp Dept Lab Med Stockholm Sweden;

Talbot Advisors Anna Maria FL USA;

Snake River Res Idaho Falls ID USA;

Victor Babes Clin Hosp Infect Dis &

Pneumophysiol Craiova Romania;

Serv Controle Infeccao Hosp Santa Casa Belo Horizonte Belo Horizonte MG Brazil;

Matei Bals Natl Inst Infect Dis Bucharest Romania;

Mercury St Med Grp Butte MT USA;

Foothills Med Ctr Alberta Hlth Serv Calgary AB Canada;

Leeds Gen Infirm Old Med Sch Microbiol Leeds W Yorkshire England;

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正文语种 eng
中图分类传染病;
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1. Cadazolid for the treatment of Clostridium difficile infection: results of two double-blind, placebo-controlled, non-inferiority, randomised phase 3 trials [J] . Gerding Dale N., Cornely Oliver A., Grill Simon, The Lancet infectious diseases . 2019,第3期

机译：菌唑胺用于治疗梭菌性艰难感染：两次双盲，安慰剂控制，非劣质性的结果，随机相3试验
2. Surotomycin versus vancomycin for Clostridium difficile infection: Phase 2, randomized, controlled, double-blind, non-inferiority, multicentre trial [J] . Lee Christine H., Patino Hernando, Stevens Chris, The Journal of Antimicrobial Chemotherapy . 2016,第10期

机译：Surotomycin vs万古霉素治疗艰难梭菌感染：2期，随机，对照，双盲，非劣效，多中心试验
3. Surotomycin versus vancomycin for Clostridium difficile infection: Phase 2, randomized, controlled, double-blind, non-inferiority, multicentre trial [J] . Lee Christine H., Patino Hernando, Stevens Chris, The Journal of Antimicrobial Chemotherapy . 2016,第10期

机译：甲甲霉素对梭菌性艰难梭菌感染的血清霉素：第2阶段，随机，控制，双盲，非劣等，多期试验
4. Detection and Quantitation of Carbohydrates in the Murine Gastrointestinal Tract Following Antibiotic Treatment and During Clostridium Difficile Infection [C] . Li Zhang, Casey Theriot, Thekkelnaycke Rajendiran, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：抗生素治疗后鼠胃肠道中碳水化合物的检测和定量及梭菌差异感染
5. A Randomized, Double-Blind, Placebo-Controlled Crossover Trial Evaluating the Effect of Intranasal Insulin on Cognition and Emotional Processing in Individuals with Treatment-Resistant Major Depressive Disorder. [D] . Cha, Danielle Soh-Young. 2016

机译：一项随机，双盲，安慰剂对照的交叉试验评估了鼻内胰岛素对难治性重度抑郁症患者认知和情绪加工的影响。
6. Efficacy and safety of ridinilazole compared with vancomycin for the treatment of Clostridium difficile infection: a phase 2 randomised double-blind active-controlled non-inferiority study [O] . Richard J Vickers, Glenn S Tillotson, Richard Nathan, -1

机译：ridinilazole与万古霉素比较治疗艰难梭菌感染的有效性和安全性：2期随机双盲主动控制非劣效性研究
7. Cadazolid for the treatment of Clostridium difficile infection: results of two double-blind, placebo-controlled, non-inferiority, randomised phase 3 trials [O] . Dale N Gerding, Oliver A Cornely, Simon Grill, 2019

机译：菌唑啉用于治疗梭菌性艰难感染：两种双盲，安慰剂控制，非劣等，随机相3试验的结果

Cadazolid for the treatment of Clostridium difficile infection: results of two double-blind, placebo-controlled, non-inferiority, randomised phase 3 trials

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