Valproic acid induces prosurvival transcriptomic changes in swine subjected to traumatic injury and hemorrhagic shock

Georgoff Patrick E.; Nikolian Vahagn C.; Higgins Gerald; Chtraklin Kiril; Eidy Hassan; Ghandour Mohamed H.; Williams Aaron; Athey Brian; Alam Hasan B.

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Valproic acid induces prosurvival transcriptomic changes in swine subjected to traumatic injury and hemorrhagic shock

机译：丙戊酸诱导猪的前刺激转录组变化，其患有创伤性损伤和出血性休克

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BACKGROUND: Valproic acid (VPA) is a histone deacetylase inhibitor that improves outcomes in large animal models of trauma. However, its protective mechanism of action is not completely understood. We sought to characterize the genetic changes induced by VPA treatment following traumatic injuries.

机译：背景：丙戊酸（VPA）是一种组蛋白脱乙酰酶抑制剂，可改善创伤的大型动物模型中的结果。然而，它的保护机制并未完全理解。我们试图表征由创伤损伤后VPA治疗诱导的遗传变化。

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来源
《The journal of trauma and acute care surgery》 |2018年第4期|共8页
作者
Georgoff Patrick E.; Nikolian Vahagn C.; Higgins Gerald; Chtraklin Kiril; Eidy Hassan; Ghandour Mohamed H.; Williams Aaron; Athey Brian; Alam Hasan B.;
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作者单位

Univ Michigan Dept Surg Ann Arbor MI 48109 USA;

Univ Michigan Dept Surg Ann Arbor MI 48109 USA;

Univ Michigan Dept Computat Med &

Bioinformat Ann Arbor MI 48109 USA;

Univ Michigan Dept Surg Ann Arbor MI 48109 USA;

Univ Michigan Dept Surg Ann Arbor MI 48109 USA;

Univ Michigan Dept Surg Ann Arbor MI 48109 USA;

Univ Michigan Dept Surg Ann Arbor MI 48109 USA;

Univ Michigan Dept Computat Med &

Bioinformat Ann Arbor MI 48109 USA;

Univ Michigan Dept Surg Ann Arbor MI 48109 USA;

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原文格式 PDF
正文语种 eng
中图分类外科学;
关键词
Valproic acid; histone deacetylase inhibitor; genomics; RNA sequencing; trauma; hemorrhage; traumatic brain injury;

机译：丙戊酸;组蛋白脱乙酰化酶抑制剂;基因组学;RNA测序;创伤;出血;创伤性脑损伤;

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专利

1. Valproic acid induces prosurvival transcriptomic changes in swine subjected to traumatic injury and hemorrhagic shock [J] . Georgoff Patrick E., Nikolian Vahagn C., Higgins Gerald, The journal of trauma and acute care surgery . 2018,第4期

机译：丙戊酸诱导猪的前刺激转录组变化，其患有创伤性损伤和出血性休克
2. Valproic Acid and Neural Apoptosis, Inflammation, and Degeneration 30 Days after Traumatic Brain Injury, Hemorrhagic Shock, and Polytrauma in a Swine Model [J] . Chang Panpan, Williams Aaron M., Bhatti Umar F., Journal of the American College of Surgeons . 2019,第3期

机译：丙戊酸和神经细胞凋亡，炎症和变性30天后血液损伤后30天后，出血休克和猪的多法罩
3. Rapid valproic acid-induced modulation of the traumatic proteome in a porcine model of traumatic brain injury and hemorrhagic shock [J] . Michael Weykamp, Vahagn C. Nikolian, Isabel S. Dennahy, Journal of Surgical Research: Clinical and Laboratory Investigation . 2018,第期

机译：快速丙甲酸诱导创伤性脑损伤的猪模型中创伤蛋白质组的调节和出血性休克
4. Traumatic brain injury caused by laser-induced shock wave in rats: A novel laboratory model for studying blast-induced traumatic brain injury [C] . Ben Hatano, Yoshihisa Matsumoto, Naoki Otani, Optical interactions with tissue and cells XXII . 2011

机译：大鼠激光诱发的冲击波引起的颅脑外伤：研究爆炸诱发的脑外伤的新型实验室模型
5. Metabolic Alterations Associated with Hemorrhagic Shock and Traumatic Injury as Measured in the Urine [D] . Lusczek, Elizabeth Rose 2011

机译：与尿液中测量的出血休克和创伤损伤相关的代谢改变
6. Hemorrhagic Shock Induces a Rapid Transcriptomic Shift of the Immune Balance in Leukocytes after Experimental Multiple Injury [O] . Lisa Debler, Annette Palmer, Sonja Braumüller, 2021

机译：出血休克在实验多重损伤后诱导白细胞免疫平衡的快速转录组转移
7. Valproic Acid and Neural Apoptosis, Inflammation, and Degeneration 30 Days after Traumatic Brain Injury, Hemorrhagic Shock, and Polytrauma in a Swine Model [O] . Panpan Chang, Aaron M. Williams, Umar F. Bhatti, 2019

机译：创伤性脑损伤，出血休克和猪的多动力后30天丙戊酸和神经细胞凋亡，炎症和退化
8. Novel Method for Inducing Therapeutic Hypothermia in a Swine Model of Blast-Induced Traumatic Brain Injury with Associated Hemorrhagic Shock. [R] . Kumar, M. M. 2012

机译：诱导伴有失血性休克的爆炸性创伤性脑损伤猪模型治疗性低温的新方法。

Valproic acid induces prosurvival transcriptomic changes in swine subjected to traumatic injury and hemorrhagic shock

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