Validity of Clinical Small-Fiber Sensory Testing to Detect Small-Nerve Fiber Degeneration

摘要

BACKGROUND: Small-nerve fiber, or small-fiber, degeneration commonly occurs in patients with peripheral neuropathies, resulting in a deterioration of nerve function. Currently, the gold standard to identify small-fiber degeneration is through skin biopsy. Simple clinical tests aim to identify small-fiber degeneration, but their validity remains unknown.