Lung lavage and Surfactant Replacement During Ex Vivo Lung Perfusion for Treatment of Gastric Acid Aspiration-Induced Donor Lung Injury

Nakajima Daisuke; Liu Mingyao; Ohsumi Akihiro; Kalaf Ricardo; Iskender Ilker; Hsin Michael; Kanou Takashi; Chen Manyin; Baer Brandon; Coutinho Rafael; Maahs Lucas; Behrens Paula; Azad Sassan; Martinu Tereza; Waddell Thomas K.; Lewis James F.; Post Martin; Veldhuizen Ruud A. W.; Cypel Marcelo; Keshavjee Shaf

首页> 外文期刊>The Journal of heart and lung transplantation: the official publication of the International Society for Heart Transplantation >Lung lavage and Surfactant Replacement During Ex Vivo Lung Perfusion for Treatment of Gastric Acid Aspiration-Induced Donor Lung Injury

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Lung lavage and Surfactant Replacement During Ex Vivo Lung Perfusion for Treatment of Gastric Acid Aspiration-Induced Donor Lung Injury

机译：肺灌洗和表面活性剂替代物在离体肺灌注期间治疗胃酸抽吸诱导的供体肺损伤

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BACKGROUND: Ex vivo lung perfusion (EVLP) provides opportunities to treat injured donor lungs before transplantation. We investigated whether lung lavage, to eliminate inflammatory inhibitory components, followed by exogenous surfactant replacement, could aid lung recovery and improve post transplant lung function after gastric aspiration injury.

机译：背景：exvivo肺灌注（EVLP）提供了在移植前治疗受伤的供体肺的机会。我们研究了肺灌洗，消除炎症抑制成分，随后进行外源性表面活性剂替代物，可以帮助肺部回收，并在胃吸入损伤后改善移植后肺功能。

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《The Journal of heart and lung transplantation: the official publication of the International Society for Heart Transplantation》 |2017年第5期|共9页
作者
Nakajima Daisuke; Liu Mingyao; Ohsumi Akihiro; Kalaf Ricardo; Iskender Ilker; Hsin Michael; Kanou Takashi; Chen Manyin; Baer Brandon; Coutinho Rafael; Maahs Lucas; Behrens Paula; Azad Sassan; Martinu Tereza; Waddell Thomas K.; Lewis James F.; Post Martin; Veldhuizen Ruud A. W.; Cypel Marcelo; Keshavjee Shaf;
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作者单位

Univ Hlth Network Toronto Gen Res Inst Latner Thorac Surg Res Labs Toronto ON Canada;

Univ Hlth Network Toronto Gen Res Inst Latner Thorac Surg Res Labs Toronto ON Canada;

Univ Hlth Network Toronto Gen Res Inst Latner Thorac Surg Res Labs Toronto ON Canada;

Univ Hlth Network Toronto Gen Res Inst Latner Thorac Surg Res Labs Toronto ON Canada;

Univ Hlth Network Toronto Gen Res Inst Latner Thorac Surg Res Labs Toronto ON Canada;

Univ Hlth Network Toronto Gen Res Inst Latner Thorac Surg Res Labs Toronto ON Canada;

Univ Hlth Network Toronto Gen Res Inst Latner Thorac Surg Res Labs Toronto ON Canada;

Univ Hlth Network Toronto Gen Res Inst Latner Thorac Surg Res Labs Toronto ON Canada;

Univ Western Ontario Dept Physiol &

Pharmacol Lawson Hlth Res Inst London ON Canada;

Univ Hlth Network Toronto Gen Res Inst Latner Thorac Surg Res Labs Toronto ON Canada;

Univ Hlth Network Toronto Gen Res Inst Latner Thorac Surg Res Labs Toronto ON Canada;

Univ Hlth Network Toronto Gen Res Inst Latner Thorac Surg Res Labs Toronto ON Canada;

Univ Hlth Network Toronto Gen Res Inst Latner Thorac Surg Res Labs Toronto ON Canada;

Univ Hlth Network Toronto Gen Res Inst Latner Thorac Surg Res Labs Toronto ON Canada;

Univ Hlth Network Toronto Gen Res Inst Latner Thorac Surg Res Labs Toronto ON Canada;

Univ Western Ontario Dept Physiol &

Pharmacol Lawson Hlth Res Inst London ON Canada;

Hosp Sick Children Physiol &

Expt Med Program Toronto ON Canada;

Univ Western Ontario Dept Physiol &

Pharmacol Lawson Hlth Res Inst London ON Canada;

Univ Hlth Network Toronto Gen Res Inst Latner Thorac Surg Res Labs Toronto ON Canada;

Univ Hlth Network Toronto Gen Res Inst Latner Thorac Surg Res Labs Toronto ON Canada;

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原文格式 PDF
正文语种 eng
中图分类器官移植术;
关键词
lung transplantation; ex vivo lung perfusion; aspiration; surfactant; lung lavage;

机译：肺移植;离体肺灌注;吸入;表面活性剂;肺灌洗;

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专利

1. Lung lavage and Surfactant Replacement During Ex Vivo Lung Perfusion for Treatment of Gastric Acid Aspiration-Induced Donor Lung Injury [J] . Nakajima Daisuke, Liu Mingyao, Ohsumi Akihiro, The Journal of heart and lung transplantation: the official publication of the International Society for Heart Transplantation . 2017,第5期

机译：肺灌洗和表面活性剂替代物在离体肺灌注期间治疗胃酸抽吸诱导的供体肺损伤
2. Surfactant treatment of aspiration-induced lung injury in children [J] . Michael A. Matthay, William Taeusch Pediatric critical care medicine: a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies . 2007,第5期

机译：表面活性剂治疗小儿吸入性肺损伤
3. Exogenous surfactant attenuates lung injury from gastric-acid aspiration during ex vivo reconditioning in pigs [J] . Khalifé-HocquemillerT., SageE., DorfmullerP., Transplantation: Official Journal of the Transplantation Society . 2014,第4期

机译：外源性表面活性剂减轻猪离体再造过程中胃酸吸入对肺部的伤害
4. Bronchopulmonary lavage with porcine-derived surfactant in acute lung injury. [C] . Acta pharmacologica sinica . 2002

机译：猪肺源性表面活性剂支气管肺灌洗治疗急性肺损伤。
5. Ex-Vivo Lung Perfusion Mediated Delivery of Rituximab to Clear Epstein-Barr Virus in Donor Lungs [D] . Ku, Terrance. 2019

机译：ex-体内肺灌注介导的rituximab递送，以在供体肺中透明epstein-barr病毒
6. Profiling inflammation and tissue injury markers in perfusate and bronchoalveolar lavage fluid during human ex vivo lung perfusion [O] . Anders S.I. Andreasson, Danai M. Karamanou, Colin S. Gillespie, -1

机译：人离体肺灌注过程中灌注液和支气管肺泡灌洗液中的炎症和组织损伤标志物分析
7. Treatment of Cytomegalovirus in Human Donor Lungs with a Novel Chemokine-Based Immunotoxin during Ex Vivo Lung Perfusion Prevents Viral Reactivation [O] . R. VP Ribeiro, T. Ku, V. H Ferreira, 2021

机译：在离体肺灌注过程中，用新型趋化因子的免疫毒素治疗人供体肺中的细胞组虫病毒防止病毒再激活

Lung lavage and Surfactant Replacement During Ex Vivo Lung Perfusion for Treatment of Gastric Acid Aspiration-Induced Donor Lung Injury

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