首页> 外文期刊>The British Journal of Nutrition >Effect of dietary consumption as a modifier on the association between FTO gene variants and excess body weight in children from an admixed population in Brazil: the Social Changes, Asthma and Allergy in Latin America (SCAALA) cohort study
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Effect of dietary consumption as a modifier on the association between FTO gene variants and excess body weight in children from an admixed population in Brazil: the Social Changes, Asthma and Allergy in Latin America (SCAALA) cohort study

机译:膳食消费作为对巴西混合人群的FTO基因变异性和儿童体重过剩的改性剂的影响:拉丁美洲(SCAALA)队列研究的社会变化,哮喘和过敏

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Previous studies have shown associations of variants of the FTO gene with body weight, but none of these have involved Latin American populations with a high level of miscegenation, as is seen in the north-eastern Brazilian population. This study evaluated the association between SNP in the FTO gene and excess weight in Salvador, Bahia, Brazil. In addition, the effect of diet as a modifier on this association was also investigated. This cross-sectional study included 1191 participants aged 4–11 years, who were genotyped for 400 variants of the FTO gene. Direct anthropometric measures were made and dietary data were obtained by 24-h food recall. Multivariate logistic regression analyses were used to assess the associations of interest. Overall, 11·2 % of the individuals included in the study were overweight/obese. Interactions were identified between the percentage energy intake from proteins and obesity risk linked to the rs62048379 SNP (P interaction=0·01) and also between fat intake (PUFA:SFA ratio) and obesity risk linked to the rs62048379 SNP (P interaction=0·01). The T allele for the variant rs62048379 was positively associated with overweight/obesity in individuals whose percentage energy intake from protein was above the median (OR 2·00; 95 % CI 1·05, 3·82). The rs62048379 SNP was also associated with overweight/obesity in individuals whose PUFA:SFA ratio was below the median (OR 1·63; 95 % CI 1·05, 2·55). The association between FTO gene variants and excess body weight can be modulated by dietary characteristics, particularly by fatty acid distribution and dietary protein intake in children.
机译:以往的研究表明,FTO基因的变异与体重的关联,但这些都不是在巴西东北部门中所见的高水平孤独的拉丁美洲人群。该研究评估了萨尔瓦多,巴西萨尔瓦多中FTO基因和体重增加的SNP之间的关联。此外,还研究了作为这种关联的改性剂的饮食的影响。这种横截面研究包括1191名年龄4-11岁的参与者,他是对FTO基因的400种变种的基因分型。制造直接人体测量措施,24小时食物召回获得膳食数据。多变量逻辑回归分析用于评估利益的协会。总体而言,11·2%包括在该研究中的个人超重/肥胖。在蛋白质和肥胖风险链接到RS62048379 SNP(P interaction = 0·01)的百分比和肥胖风险之间鉴定了相互作用,并且在脂肪摄入(PUFA:SFA比率)和肥胖风险与RS62048379 SNP相关联(P Interaction = 0)之间·01)。变体RS62048379的T等位基因与蛋白质百分比(或2·00; 95%CI 1·05,3·82)的能量摄入百分比的百分比上高于中值(或2·00。 RS62048379 SNP还与PUFA:SFA比率低于中位数(或1·63; 95%CI 1·05,2·55)的个体中的超重/肥胖有关。 FTO基因变体和过量体重之间的关联可以通过膳食特征调节,特别是通过脂肪酸分布和儿童的膳食蛋白摄入量。

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