Long‐term complications and reconstruction failures in previously radiated breast cancer patients receiving salvage mastectomy with autologous reconstruction or tissue expander/implant‐based reconstruction

摘要

Abstract Salvage mastectomy (SM) is the standard of care for patients with local recurrence (LR) after breast conservation therapy (BCT), often with immediate reconstruction. Complications of reconstruction are a concern for these patients, and long‐term data are limited. We sought to compare rates of complications requiring re‐operation (CRR) and reconstruction failure (RF) between autologous reconstruction (AR) and tissue expander/implant reconstruction (TE/I). Patients with locally recurrent breast cancer after BCT, treated with SM and immediate AR or TE/I between 2000 and 2008, were identified. CRR was defined as unplanned return to operating room for wound infection, dehiscence, necrosis (including flap, skin, or fat), hematoma, or hernia (for AR) and extrusion, leak, or capsular contracture (for TE/I). RF was defined as conversion to another reconstruction technique or to flat chest wall. This study included 103 patients with 107 reconstructions. Median follow‐up was 6.6?years. CRR and RF were significantly higher with TE/I (n?=?34) compared to AR (n?=?73) at 5?years (50.9% vs 25.5%; P ?=?0.02) and (42.1% vs 5.8%; P ??0.001). On univariate analysis (UVA), TE/I (HR?=?2.14; P ?=?0.02) and diabetes (HR?=?5.10; P ?=?0.007) were significant predictors for CRR. On UVA, TE/I (HR?=?7.30; P ??0.001) and older age at reconstruction (HR?=?1.03; P ?=?0.003) were significant predictors for RF. In this population of previously irradiated patients, TE/I was associated with significantly higher CRR and RF. Complications continue to occur up to 10?years after TE/I. AR should be considered in appropriately selected patients, though TE/I may remain a reasonable option in patients without high‐risk factors for surgical complications.