Fenofibrate Attenuates Malignant Hypertension by Suppression of the Renin-angiotensin System: A Study in Cyp1a1-Ren-2 Transgenic Rats

Jichova Sarka; Dolezelova Sarka; Kopkan Libor; Kompanowska-Jezierska Elzbieta; Sadowski Janusz; Cervenka Ludek

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Fenofibrate Attenuates Malignant Hypertension by Suppression of the Renin-angiotensin System: A Study in Cyp1a1-Ren-2 Transgenic Rats

机译：细胞纤维酸盐通过抑制肾素 - 血管紧张素系统衰减恶性高血压：CYP1A1-REN-2转基因大鼠的研究

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Background: Malignant hypertension is a life-threatening condition, and its pathophysiology is still poorly understood. The present study was designed to evaluate the role of interaction of the renin-angiotensin system with 20-hydroxyeicosatetraenoic acid (20-HETE), a product of cytochrome P450 (CYP) dependent omega-hydroxylase pathway, in the pathophysiology of angiotensin II (ANG II) dependent malignant hypertension in Cyp1a1-Ren-2 transgenic rats.

机译：背景：恶性高血压是一种危及生命的病情，其病理生理学仍然很清楚。本研究旨在评估肾素 - 血管紧张素体系与20-羟基辛杂辛酸（20-HETE）的相互作用，在血管紧张素II的病理生理学中（ANG II）CYP1A1-REN-2转基因大鼠依赖性恶性高血压。

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来源
《The American Journal of the Medical Sciences》 |2016年第6期|共13页
作者
Jichova Sarka; Dolezelova Sarka; Kopkan Libor; Kompanowska-Jezierska Elzbieta; Sadowski Janusz; Cervenka Ludek;
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作者单位

Inst Clin &

Expt Med Ctr Expt Med 1958-9 Videnska CZ-14000 Prague 4 Czech Republic;

Inst Clin &

Expt Med Ctr Expt Med 1958-9 Videnska CZ-14000 Prague 4 Czech Republic;

Inst Clin &

Expt Med Ctr Expt Med 1958-9 Videnska CZ-14000 Prague 4 Czech Republic;

Polish Acad Sci Dept Renal &

Body Fluid Physiol Mossakowski Med Res Ctr Warsaw Poland;

Polish Acad Sci Dept Renal &

Body Fluid Physiol Mossakowski Med Res Ctr Warsaw Poland;

Inst Clin &

Expt Med Ctr Expt Med 1958-9 Videnska CZ-14000 Prague 4 Czech Republic;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
Malignant hypertension; Renin-angiotensin system; Cytochrome P450 metabolites; 20-hydroxyeicosatetraenoic acid;

机译：恶性高血压;肾素 - 血管紧张素系统;细胞色素p450代谢物;20-羟基辛苷;

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1. Fenofibrate Attenuates Malignant Hypertension by Suppression of the Renin-angiotensin System: A Study in Cyp1a1-Ren-2 Transgenic Rats [J] . Jichova Sarka, Dolezelova Sarka, Kopkan Libor, The American Journal of the Medical Sciences . 2016,第6期

机译：细胞纤维酸盐通过抑制肾素 - 血管紧张素系统衰减恶性高血压：CYP1A1-REN-2转基因大鼠的研究
2. Inhibition of soluble epoxide hydrolase improves the impaired pressure-natriuresis relationship and attenuates the development of hypertension and hypertension-associated end-organ damage in Cyp1a1-Ren-2 transgenic rats. [J] . Honetschlagerova Z, Sporkova A, Kopkan L, Journal of hypertension . 2011,第8期

机译：抑制可溶性环氧化物水解酶可改善Cyp1a1-Ren-2转基因大鼠的压力与利尿关系，并减轻高血压的发展以及与高血压相关的终末器官损害。
3. Renal Nitric Oxide Synthase and Antioxidant Preservation in Cyp1a1-Ren-2 Transgenic Rats With Inducible Malignant Hypertension [J] . Cunningham Mark W. Jr., Sasser Jennifer M., West Crystal A., American Journal of Hypertension . 2013,第10期

机译：CYP1a1-Ren-2转基因大鼠诱发性恶性高血压的肾脏一氧化氮合酶和抗氧化保存
4. USING ACTIVE VIBRATION SUPPRESSION SYSTEMS FOR COST REDUCTION IN DEVELOPING ROTORCRAFT PASSIVE VIBRATION ATTENUATION SYSTEM SPECIFICATIONS [C] . Peter Scheidler, Marko Vuga Annual international symposium of the Society of Flight Test . 2012

机译：使用主动振动抑制系统来降低旋翼机被动振动衰减系统规格中的成本
5. New advances on the biochemical pathways in the renin-angiotensin system in hypertension and their role in cardiac structure and function [D] . Trask, Aaron J. 2008

机译：高血压肾素-血管紧张素系统生化途径及其在心脏结构和功能中的作用的新进展
6. 20-Hydroxyeicosatetraenoic acid antagonist attenuates the development of malignant hypertension and reverses it once established: a study in Cyp1a1-Ren-2 transgenic rats [O] . Lenka Sedláková, Soňa Kikerlová, Zuzana Husková, 2018

机译：20-羟基己二酸四烯酸拮抗剂可减轻恶性高血压的发生并逆转其一旦建立：在Cyp1a1-Ren-2转基因大鼠中的一项研究
7. 20-Hydroxyeicosatetraenoic acid antagonist attenuates the development of malignant hypertension and reverses it once established: a study in Cyp1a1-Ren-2 transgenic rats [O] . Lenka Sedláková, Soňa Kikerlová, Zuzana Husková, 2018

机译：20-羟基喹喔啉酸拮抗剂衰减恶性高血压的发育，曾经建立则逆转：CYP1A1-REN-2转基因大鼠的研究
8. Generation of Transgenic Animals Producing Ezymatically Active Prostate- Specific Antigen (PSA) in Normal and Malignant Prostate Tissue [R] . Denmeade, S. R. 2005

机译：在正常和恶性前列腺组织中产生具有活性前列腺特异性抗原（psa）的转基因动物的产生

Fenofibrate Attenuates Malignant Hypertension by Suppression of the Renin-angiotensin System: A Study in Cyp1a1-Ren-2 Transgenic Rats

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