Adjuvant vs. salvage radiotherapy for patients at high risk for recurrence after radical prostatectomy

摘要

Prostate cancer patients with adverse pathologic factors (i.e., positive surgical margin. pT3 disease) after radical prostatectomy are more likely not cured ( >60%) than cured by surgery alone. Adjuvant radiotherapy compared with observation reduces recurrence by 49% to 57%, may improve overall survival, and improves long-term quality of life without increased long-term patient-reported urinary or gastrointestinal tract symptoms. Despite these results. adjuvant radiotherapy is uncommonly received by patients with these adverse factors.