Traumatic stress and accelerated DNA methylation age: A meta-analysis

Wolf Erika J.; Maniates Hannah; Nugent Nicole; Maihofer Adam X.; Armstrong Don; Ratanatharathorn Andrew; Ashley-Koch Allison E.; Garrett Melanie; Kimbrel Nathan A.; Lori Adriana; Aiello Allison E.; Baker Dewleen G.; Beckham Jean C.; Boks Marco P.; Galea Sandro; Geuze Elbert; Hauser Michael A.; Kessler Ronald C.; Koenen Karestan C.; Miller Mark W.; Ressler Kerry J.; Risbrough Victoria; Rutten Bart P. P.; Stein Murray B.; Ursano Robert J.; Vermetten Eric; Vinkers Christiaan H.; Uddin Monica; Smith Alicia K.; Nievergelt Caroline M.; Logue Mark W.

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Traumatic stress and accelerated DNA methylation age: A meta-analysis

机译：创伤应激和加速DNA甲基化年龄：META分析

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Background: Recent studies examining the association between posttraumatic stress disorder (PTSD) and accelerated aging, as defined by DNA methylation-based estimates of cellular age that exceed chronological age, have yielded mixed results.

机译：背景：最近研究检测到的前后应激障碍（PTSD）和加速衰老之间的关联，如通过比较年龄的DNA甲基化的细胞年龄估计所定义，产生了混合结果。

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《Psychoneuroendocrinology: An International Journal 》 |2018年第2018期| 共12页
作者
Wolf Erika J.; Maniates Hannah; Nugent Nicole; Maihofer Adam X.; Armstrong Don; Ratanatharathorn Andrew; Ashley-Koch Allison E.; Garrett Melanie; Kimbrel Nathan A.; Lori Adriana; Aiello Allison E.; Baker Dewleen G.; Beckham Jean C.; Boks Marco P.; Galea Sandro; Geuze Elbert; Hauser Michael A.; Kessler Ronald C.; Koenen Karestan C.; Miller Mark W.; Ressler Kerry J.; Risbrough Victoria; Rutten Bart P. P.; Stein Murray B.; Ursano Robert J.; Vermetten Eric; Vinkers Christiaan H.; Uddin Monica; Smith Alicia K.; Nievergelt Caroline M.; Logue Mark W.;
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作者单位

VA Boston Healthcare Syst Natl Ctr PTSD Boston MA USA;

VA Boston Healthcare Syst Natl Ctr PTSD Boston MA USA;

Rhode Isl Hosp Bradley Hasbro Childrens Res Ctr Providence RI USA;

Univ Calif San Diego Dept Psychiat San Diego CA USA;

Univ Illinois Carl R Woese Inst Genom Biol Urbana IL USA;

Columbia Univ Dept Epidemiol New York NY USA;

Duke Univ Sch Med Duke Mol Physiol Inst Durham NC USA;

Duke Univ Metr Ctr Dept Psychiat &

Behav Sci Durham NC USA;

Duke Univ Metr Ctr Dept Psychiat &

Behav Sci Durham NC USA;

Emory Univ Dept Psychiat &

Behav Sci Atlanta GA USA;

Univ N Carolina Chapel Hill Gillings Sch Global Publ Hlth Dept Epidemiol Chapel Hill NC USA;

Univ Calif San Diego Dept Psychiat San Diego CA USA;

Duke Univ Metr Ctr Dept Psychiat &

Behav Sci Durham NC USA;

Univ Med Ctr Utrecht Brain Ctr Rudolf Magnus Dept Psychiat Utrecht Netherlands;

Boston Univ Sch Publ Hlth Boston MA USA;

Univ Med Ctr Utrecht Brain Ctr Rudolf Magnus Dept Psychiat Utrecht Netherlands;

Duke Univ Sch Med Duke Mol Physiol Inst Durham NC USA;

Harvard Med Sch Dept Hlth Care Policy Boston MA USA;

Harvard T H Chan Sch Publ Hlth Dept Epidemiol Boston MA USA;

VA Boston Healthcare Syst Natl Ctr PTSD Boston MA USA;

Harvard Med Sch Dept Psychiat Belmont MA USA;

Univ Calif San Diego Dept Psychiat San Diego CA USA;

Maastricht Univ Med Ctr Sch Mental Hlth &

Neurosci Dept Psychiat &

Neuropsychol Maastricht;

Univ Calif San Diego Dept Psychiat San Diego CA USA;

Uniformed Serv Univ Hlth Sci Ctr Study Traumat Stress Dept Psychiat Bethesda MD USA;

Univ Med Ctr Utrecht Brain Ctr Rudolf Magnus Dept Psychiat Utrecht Netherlands;

Univ Med Ctr Utrecht Brain Ctr Rudolf Magnus Dept Psychiat Utrecht Netherlands;

Univ Illinois Carl R Woese Inst Genom Biol Urbana IL USA;

Emory Univ Dept Psychiat &

Behav Sci Atlanta GA USA;

Univ Calif San Diego Dept Psychiat San Diego CA USA;

VA Boston Healthcare Syst Natl Ctr PTSD Boston MA USA;

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原文格式 PDF
正文语种 eng
中图分类神经病学与精神病学 ;
关键词
DNA methylation; Traumatic stress; PTSD; Accelerated aging; Meta-analysis; Epigenetic clock;

机译：DNA甲基化;创伤应激;PTSD;加速老化;META分析;表观遗传时钟;

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专利

1. Traumatic stress and accelerated DNA methylation age: A meta-analysis [J] . Wolf Erika J., Maniates Hannah, Nugent Nicole, Psychoneuroendocrinology: An International Journal . 2018 ,第期

机译：创伤应激和加速DNA甲基化年龄：META分析
2. Traumatic stress‐induced persistent changes in DNA DNA methylation regulate neuropeptide Y expression in rat jejunum [J] . Sagarkar S., Mahajan S., Choudhary A. G., Neurogastroenterology and motility . 2017 ,第9期

机译：创伤性应激诱导的DNA DNA甲基化持续变化调节大鼠Jejunum中的神经肽Y表达
3. Post-traumatic stress disorder Levels of cortisol and oxidative stress and DNA damage in child and adolescent victims of sexual abuse with or without post-traumatic stress disorder [J] . Simsek S, Yuksel T, Kaplan I, Bulletin of Clinical Psychopharmacology . 2015 ,第Supplementa1期

机译：创伤后应激障碍有或没有创伤后应激障碍的性虐待儿童和青少年受害者的皮质醇和氧化应激水平以及DNA损伤水平
4. Utilize Imputation Method and Meta-analysis to Identify DNA-Methylation-Mediated microRNAs in Ovarian Cancer [C] . Ezra B. Wijaya, Erwandy Lim, David Agustriawan, International conference on algorithms for computational biology . 2018

机译：利用归因法和荟萃分析鉴定卵巢癌中DNA甲基化介导的microRNA。
5. Hyperhomocysteinemia accelerates thrombosis through ICAM-1 dependent endothelial activation and DNA hypomethylation. [D] . Meng, Shu. 2013

机译：高同型半胱氨酸血症通过ICAM-1依赖性内皮激活和DNA低甲基化促进血栓形成。
6. Traumatic Stress and Accelerated DNA Methylation Age: A Meta-Analysis [O] . Erika J. Wolf, Hannah Maniates, Nicole Nugent, -1

机译：创伤应激和加速的DNA甲基化年龄：荟萃分析
7. DNA methylation levels are associated with CRF1 receptor antagonist treatment outcome in women with post-traumatic stress disorder [O] . Julius C. Pape, Tania Carrillo-Roa, Barbara O. Rothbaum, 2018

机译：DNA甲基化水平与具有创伤后应激障碍的妇女的CRF1受体拮抗剂治疗结果有关

Traumatic stress and accelerated DNA methylation age: A meta-analysis

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