PREDICTION OF TUBULOINTERSTITIAL INJURY IN CHRONIC KIDNEY DISEASE USING A NON-INVASIVE MODEL: COMBINATION OF RENAL SONOGRAPHY AND LABORATORY BIOMARKERS

摘要

The goal of the study described here was to evaluate the degree of tubulointerstitial injury in patients with chronic kidney disease (CKD) using a more accurate model that combines renal sonographic parameters and laboratory biomarkers. Atotal of 308 patients were enrolled. The study protocol included conventional ultrasound, contrast-enhanced ultrasonography and renal biopsy. CKD patients were divided into normal and mild (= 25%), moderate (26%-50%) and severe (50%) tubulointerstitial injury groups. We created a model comprising peak intensity, time to peak, urinary retinol-binding protein and beta(2)-microglobulin that could discriminate severe (50%) tubulointerstitial injury. The area under the receiver operating characteristic curve of this model was 0.832, which had better accuracy than other individual indexes, and the sensitivity and specificity were 74.2% and 82.8%, respectively. Therefore, this model may be used to evaluate the severity of tubulointerstitial injury and may have the potential to serve as an effective auxiliary method to help nephrologists evaluate patients with CKD. (E-mail: lihliwl@163.com) (c) 2018World Federation for Ultrasound in Medicine & Biology. All rights reserved.