Taxonomy for colorectal cancer screening promotion: Lessons from recent randomized controlled trials

摘要

Abstract Objective To derive a taxonomy for colorectal cancer screening that advances Randomized Controlled Trials (RCTs) and screening uptake. Design Detailed publication review, multiple interviews with principal investigators (PIs) and collaboration with PIs as co-authors produced a CRCS intervention taxonomy. Semi-structured interview questions with PIs (Drs. Inadomi, Myers, Green, Gupta, Jerant and Ritvo) yielded details about trial conduct. Interview comparisons led to an iterative process informing serial interviews until a consensus was obtained on final taxonomy structure. Results These taxonomy headings ( E ngagement Sponsor, P opulation Targeted, A lternative Screening Tests, D elivery Methods, and S upport for Test Performance ( EPADS )) were used to compare studies. Exemplary insights emphasized: 1) direct test delivery to patients; 2) linguistic-ethnic matching of staff to minority subjects; and 3) authorization of navigators to schedule or refer for colonoscopies and/or distribute stool blood tests during screening promotion. Conclusion PIs of key RCTs (2012–2015) derived a CRCS taxonomy useful in detailed examination of CRCS promotion and design of future RCTs. Highlights ? We developed a colorectal cancer screening taxonomy to guide future research. ? Principal investigators of 6 major randomized controlled trials were interviewed. ? The interview data derived was not previously reported in published articles. ? Interview analyses revealed 5 taxonomy headings for ordering novel study comparisons. ? The taxonomy was then applied to better understandings of 11 studies. ]]>