Distribution of MCH-containing fibers in the feline brainstem: Relevance for REM sleep regulation

摘要

Neurons that utilize melanin-concentrating hormone (MCH) as a neuromodulator are localized in the posterolateral hypothalamus and incerto-hypothalamic area. These neurons project diffusely throughout the central nervous system and have been implicated in critical physiological processes, such as sleep. Unlike rodents, in the order carnivora as well as in humans, MCH exerts its biological functions through two receptors: MCHR-1 and MCHR-2. Hence, the cat is an optimal animal to model MCHergic functions in humans.