Early- and late-onset preeclampsia and the tissue-specific epigenome of the placenta and newborn

摘要

Introduction: Preeclampsia (PE) carries increased risks of cardiovascular-and metabolic diseases in mothers and offspring during the life course. While the severe early-onset PE (EOPE) phenotype originates from impaired placentation in early pregnancy, late-onset PE (LOPE) is in particular associated with pre-existing maternal cardiovascular-and metabolic risk factors. We hypothesize that PE is associated with altered epigenetic programming of placental and fetal tissues and that these epigenetic changes might elucidate the increased cardiovascular-and metabolic disease susceptibility in PE offspring.