Solid-liquid phase equilibrium and mixing thermodynamic analysis of coumarin in binary solvent mixtures

摘要

The solubility of coumarin in three aqueous solvent mixtures (methanol + water, ethanol + water and acetone + water) was experimentally determined by a gravimetric method at atmospheric pressure. The experimental solubility data were fitted using the modified Apelblat equation, non-random two-liquid (NRTL) equation, the combined nearly ideal binary solvent/Redlich-Kister equation and the Jouyban-Acree equation, respectively. All the equations were proven to be able to correlate the experimental data, and the modified Apelblat equation could obtain better correlation results than the other three models. The solubility of coumarin increases with increase in temperature. At the same temperature, the solubility increases with increase in mole fraction of organic solvents except for the ethanol-water system which shows a unimodal curve. In addition, the apparent thermodynamic properties of the mixing process were calculated based on the NRTL model and the experimental solubility data.