Matrix metalloproteinase in acral and non-acrai vitiligo

摘要

Repigmentation in vitiligo requires activation, proliferation, and migration of the melanoblasts and melanocytes into the depigmented epidermis. Cell migration involves modifications of the architecture of cells which requires activation of enzymes that are involved in ECM degradation such as matrix metalloproteinases (MMPs). The significant reduction in their expression in vitiliginous skin has been previously demonstrated and thereby incriminated to share in reducing the migration of melanocytes and their precursors. Phototherapy in the form of narrow band UVB and photoche-motherapy (PUVA) are still considered the pillar in the treatment of vitiligo. Among a vast array of effects that could account for their efficacy, it has been demonstrated that UVA can lead to increased expression of MMPs which could aid in the process of repigmentation of vitiliginous lesions. In the current work, we aimed at detection of the differences between acral and non-acral vitiligo skin as regards the expression of three members of the MMP family; MMP1, MMP2, and MMP9, and how would they change after PUVA therapy.