FbD Supported Development and In Vitro Evaluation of Carbomer based Resveratrol Loaded Topical Antipsoriatic Nanoemulgel for its Targeted Skin Delivery

摘要

Background: Resveratrol is a wonder therapy for the treatment of several skindisorders, including psoriasis, but its skin permeation limits its applications.Objective: The present work dealt with optimizing and formulating resveratrol loaded vitaminE based nanoemulsion and carbomer based nanoemulgel intended for topical applicationin the treatment of plaque psoriasis.The major objective of this study was to achieve the quality target product profile with respectto enhanced skin permeation and superior skin deposition of the formulatednanoemulgel to achieve the superlative therapeutic advantages.Methods: Formulation by design (FbD) approach was employed to optimize varied criticalmaterial attributes such as the concentration of oil and Smix to achieve the desired qualitycharacteristics. Carbomer based nanoemulgel was formulated and evaluated.Results: Optimized formulation was having globule size (168.3 ± 4.98 nm), percentagecumulative permeation (4.81 ± 0.65%), permeation flux (7.62 ± 0.39 μg hr-1cm-2), and skindeposition (668.65 ± 11.98 μg cm-2). Nanoemulgel was found to have optimum physicalproperties in terms of viscosity, spreadability, pH and physical stability. The extent of skindeposition was approximately 6.682 times higher while the permeation enhancement ratiowas around 2.872 as compared to conventional formulation indicating its higher skin targetingabilities, which was further ratified by Confocal Laser Scanning Microscopy results.Conclusion: Nanoemulgel formulated by the current FbD approach has enhanced skinpermeation and skin deposition properties as compared to conventional carbomer gel.Thus, it could augment the therapeutic benefits of encapsulated bioactive in the treatmentof several skin disorders like psoriasis.