Structure and Analgesic Activity of 13-(N-Aryl(N,N-Diethyl)Aminocarbonyl)-9-Methyl-11-Thioxo-8-Oxa-10,12-Diazatricyclo [7.3.1.0(2,7)]Trideca-2,4,6-Trienes and Their 10-N-Phenyl Derivatives

Gein V. L.; Zamaraeva T. M.; Buzmakova N. A.; Rudakova I. P.; Dmitriev M. V.

首页> 外文期刊>Pharmaceutical Chemistry Journal >Structure and Analgesic Activity of 13-(N-Aryl(N,N-Diethyl)Aminocarbonyl)-9-Methyl-11-Thioxo-8-Oxa-10,12-Diazatricyclo [7.3.1.0(2,7)]Trideca-2,4,6-Trienes and Their 10-N-Phenyl Derivatives

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Structure and Analgesic Activity of 13-(N-Aryl(N,N-Diethyl)Aminocarbonyl)-9-Methyl-11-Thioxo-8-Oxa-10,12-Diazatricyclo [7.3.1.0(2,7)]Trideca-2,4,6-Trienes and Their 10-N-Phenyl Derivatives

机译：结构和镇痛活性为13-（N-芳基（N，N-二乙基）氨基羰基）-9-甲基-11-硫代氧基-8-氧气-10,12-二氮杂环[7.3.1.0（2,7）] Trideca- 2,4,6-三烯及其10-苯基衍生物

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The structure and analgesic activity of 13-(N-aryl(N,N-diethyl)-aminocarbonyl)-9-methyl-11-thioxo-8-oxa-10,12-diazatricyclo[7.3.1.0(2,7)]trideca-2,4,6-trienes and their 10-N-phenyl derivatives were studied. The studied compounds were shown to possess analgesic activity with low acute toxicity.

机译：13-（N-芳基（N，N，N-二乙基） - 氨基羰基）-9-甲基-11-硫代氧基-8- OXA-10,12-二氮杂基-8- OXA-10,12-二氮杂基的结构和镇痛活性[7.3.1.0（2,7）] 研究了Trideca-2,4,6------其10-苯基衍生物。所研究的化合物被证明具有低急性毒性的镇痛活性。

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《Pharmaceutical Chemistry Journal》 |2018年第6期|共3页
作者
Gein V. L.; Zamaraeva T. M.; Buzmakova N. A.; Rudakova I. P.; Dmitriev M. V.;
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作者单位

Perm State Pharmaceut Acad Minist Hlth Russian Federat 2 Polevaya St Perm 614990 Russia;

Perm State Pharmaceut Acad Minist Hlth Russian Federat 2 Polevaya St Perm 614990 Russia;

Perm State Pharmaceut Acad Minist Hlth Russian Federat 2 Polevaya St Perm 614990 Russia;

Perm State Pharmaceut Acad Minist Hlth Russian Federat 2 Polevaya St Perm 614990 Russia;

Perm State Natl Res Univ 15 Bukireva St Perm 614000 Russia;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
three-component reaction; N-aryl(N; N-diethyl)amides of acetoacetic acid; salicylaldehyde; thiourea; phenylthiourea; sodium bisulfate; 9-methyl-11-thioxo-8-oxa-10; 12-diazatricyclo7; 3; 1; 02; 7 trideca-2; 4; 6-trienes; x-ray crystal structure analysis; analgesic activity; acute toxicity;

机译：三分组分反应;乙酰乙酸的N-芳基（N-二乙基）酰胺;水杨醛;硫脲;苯硫脲;二硫酸钠;9-甲基-11-硫代XO-8- OXA-10;12-二氮酸[7;3;1;02;7 Trideca-2;4;6-三烯;X射线晶体结构分析;镇痛活动;急性毒性;

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1. Structure and Analgesic Activity of 13-(N-Aryl(N,N-Diethyl)Aminocarbonyl)-9-Methyl-11-Thioxo-8-Oxa-10,12-Diazatricyclo [7.3.1.0(2,7)]Trideca-2,4,6-Trienes and Their 10-N-Phenyl Derivatives [J] . Gein V. L., Zamaraeva T. M., Buzmakova N. A., Pharmaceutical Chemistry Journal . 2018,第6期

机译：结构和镇痛活性为13-（N-芳基（N，N-二乙基）氨基羰基）-9-甲基-11-硫代氧基-8-氧气-10,12-二氮杂环[7.3.1.0（2,7）] Trideca- 2,4,6-三烯及其10-苯基衍生物
2. Synthesis of N-aryl- and N,N-diethyl-9-methyl-11-sulfanylidene-8-oxa-10,12-diazatricyclo[7.3.1.0(2,7)]trideca-2,4,6-triene-13-carboxamides [J] . Zamaraeva T. M., Gein V. L., Buzmakova N. A., Russian Journal of Organic Chemistry . 2016,第7期

机译：N-芳基和N，N-二乙基-9-甲基-11-亚磺酰基-8-oxa-10,12-二氮杂三环[7.3.1.0（2,7）] trideca-2,4,6-triene-的合成13-羧酰胺
3. Crystal structure of 1-(4-bromo-9-methyl-11-thioxo-8-oxa-10,12-diazatricyclo[7.3.1.0~(2.7)]trideca-2,4,6-trien-13-yl)ethanone [J] . Kurbanova M.M., Kurbanov A.V., Novruzova A.B., Journal of structural chemistry . 2010,第5期

机译：1-（4-溴-9-甲基-11-thioxo-8-oxa-10,12-二氮杂三环[7.3.1.0〜（2.7）] trideca-2,4,6-trien-13-yl的晶体结构乙酮
4. Quantitative structure-activity relationship (QSAR) modelling of N-aryl derivatives as cholinesterase inhibitors [C] . Ridzuan Mohd Syafiq Mohammad, Jaafar Mohd Zuli, Zain Mazatulikhma Mat 2012 IEEE Symposium on Humanities, Science and Engineering Research . 2012

机译：N-芳基衍生物作为胆碱酯酶抑制剂的定量构效关系（QSAR）模型
5. Synthesis and crystal structure of 10-hydroxy-4-methoxy-5,9-dimethyl-tricyclo3.3.1.02,7trideca-2,4,6-triene-13-one [O] . M. Soriano-Garcia, R. Villena Iribe, A. Covarrubias, 1993

机译：10-羟基-4-甲氧基-5,9-二甲基 - 三环的合成和晶体结构3.3.1.02,7 Trideca-2,4,6-三烯-13-1

Structure and Analgesic Activity of 13-(N-Aryl(N,N-Diethyl)Aminocarbonyl)-9-Methyl-11-Thioxo-8-Oxa-10,12-Diazatricyclo [7.3.1.0(2,7)]Trideca-2,4,6-Trienes and Their 10-N-Phenyl Derivatives

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