Novel cytochrome P450 (CYP6D1) and voltage sensitive sodium channel (Vssc) alleles of the house fly (Musca domestica) and their roles in pyrethroid resistance

Pan Jing; Yang Chan; Liu Yan; Gao Qi; Li Mei; Qiu Xinghui

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Novel cytochrome P450 (CYP6D1) and voltage sensitive sodium channel (Vssc) alleles of the house fly (Musca domestica) and their roles in pyrethroid resistance

机译：新型细胞色素P450（CYP6D1）和电压敏感钠通道（VSSC）的房屋飞（Musca Domestica）及其在拟除虫菊酯抗性中的作用

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BACKGROUNDThe house fly Musca domestica is an important disease vector. Point mutation-mediated target-site insensitivity of the voltage sensitive sodium channel (VSSC) and increased detoxification mediated by cytochrome P450 (CYP6D1) overexpression have been characterized as two major mechanisms of pyrethroid resistance. In this study, genetic mutations in the Vssc and CYP6D1 genes and their contribution to pyrethroid resistance were investigated.

机译：背景房屋飞行马斯卡国内是一个重要疾病传染媒介。点突变介导的电压敏感钠通道（VSSC）的靶位点不敏感性和通过细胞色素P450（CYP6D1）过表达介导的增加的排毒已经表征为拟除虫菊酯抗性的两个主要机制。在该研究中，研究了VSSC和CYP6D1基因中的基因突变及其对拟除虫菊酯抗性的贡献。

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来源
《Pest Management Science》 |2018年第4期|共9页
作者
Pan Jing; Yang Chan; Liu Yan; Gao Qi; Li Mei; Qiu Xinghui;
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作者单位

Chinese Acad Sci Inst Zool State Key Lab Integrated Management Pest Insects Beijing 100101 Peoples R China;

Chinese Acad Sci Inst Zool State Key Lab Integrated Management Pest Insects Beijing 100101 Peoples R China;

Chinese Acad Sci Inst Zool State Key Lab Integrated Management Pest Insects Beijing 100101 Peoples R China;

Chinese Acad Sci Inst Zool State Key Lab Integrated Management Pest Insects Beijing 100101 Peoples R China;

Chinese Acad Sci Inst Zool State Key Lab Integrated Management Pest Insects Beijing 100101 Peoples R China;

Chinese Acad Sci Inst Zool State Key Lab Integrated Management Pest Insects Beijing 100101 Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类植物保护;
关键词
CYP6D1; evolution; Musca domestica; pyrethroid resistance; voltage sensitive sodium channel (Vssc);

机译：CYP6D1;进化;Musca Domestica;拟除虫菊酯抗性;电压敏感钠通道（VSSC）;

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1. Novel cytochrome P450 (CYP6D1) and voltage sensitive sodium channel (Vssc) alleles of the house fly (Musca domestica) and their roles in pyrethroid resistance [J] . Pan Jing, Yang Chan, Liu Yan, Pest Management Science . 2018,第4期

机译：新型细胞色素P450（CYP6D1）和电压敏感钠通道（VSSC）的房屋飞（Musca Domestica）及其在拟除虫菊酯抗性中的作用
2. Frequencies of pyrethroid resistance-associated mutations of Vssc1 and CYP6D1 in field populations of Musca domestica L. in Turkey [J] . Vatan Ta?k?n, Sibel Ba?kurt, Ersin Do?a?, Journal of vector ecology: journal of the Society for Vector Ecology . 2011,第2期

机译：土耳其家蝇田间种群中与拟除虫菊酯抗药性相关的Vssc1和CYP6D1突变的频率
3. Frequencies of pyrethroid resistance‐associated mutations of Vssc1 and CYP6D1 in field populations of Musca domestica L. in Turkey [J] . Vatan Ta#x15f, k#x131, n, Journal of vector ecology: journal of the Society for Vector Ecology . 2011,第2期

机译：土耳其家蝇田间种群中拟除虫菊酯抗药性相关的Vssc1和CYP6D1突变频率
4. Evaluating the role of cytochrome P450s in pyrethroid resistance of the diamondback moth, Plutella xylostetta (L.) [C] . M A M Bautista, K Miura, T Miyata, International Plant Protection Congress . 2007

机译：评价细胞色素P450s在蛋白质母背蛾的拟除虫菊酯抗性中的作用，Plutella Xylostetta（L.）
5. Molecular mechanisms of cytochrome P450 monooxygenase-mediated pyrethroid resistance in the house fly, Musca domestica (L.). [D] . Zhu, Fang. 2007

机译：家蝇蝇中细胞色素P450单加氧酶介导的拟除虫菊酯抗性的分子机制。
6. Three mutations identified in the voltage-sensitive sodium channel α-subunit gene of permethrin-resistant human head lice reduce the permethrin sensitivity of house fly Vssc1 sodium channels expressed in Xenopus oocytes [O] . Kyong SupYoon, Steven B. Symington, Si Hyeock Lee, -1

机译：耐氯菊酯的人头虱的电压敏感钠通道α-亚基基因中鉴定的三个突变降低了非洲爪蟾卵母细胞中表达的家蝇Vssc1钠通道对氯菊酯的敏感性
7. B-41 Molecular mechanism involved in increased expression of a cytochrome P450 responsible for pyrethroid resistance in the housefly, Musca domestica [O] . T. Tomita, Nannan Liu, Jeffrey G. Scott 1995

机译：B-41分子机制涉及杂草，Musca domestica中捕集拟除虫菊酯抗性的细胞色素P450的表达增加

Novel cytochrome P450 (CYP6D1) and voltage sensitive sodium channel (Vssc) alleles of the house fly (Musca domestica) and their roles in pyrethroid resistance

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