Evaluation of the prognostic value of neutrophil to lymphocyte ratio in patients with hypertriglyceridemia-induced acute pancreatitis

摘要

Abstract Introduction Recent studies attribute promising prognostic values to various inflammatory biomarkers in acute pancreatitis, including the following: the neutrophil–lymphocyte ratio (NLR), platelet–lymphocyte ratio (PLR), and red cell distribution width (RDW). We aimed to determine the performance of these biomarkers for detecting disease severity in patients with hypertriglyceridemia-induced acute pancreatitis (HTG-AP). Methods We retrospectively reviewed 110 patients with HTG-AP and compared the NLR, PLR, and RDW in different severity groups. We performed receiver-operating characteristic (ROC) analysis to identify the optimal cut-off value for NLR to predict severe AP. Results NLR was significantly higher in patients with severe AP than mild and moderately severe AP (14.6 vs. 6.9, p ? p ?=?0.026). After dichotomization by the optimal cut-off value of 10 as determined by the ROC curve, the high-NLR group had a significantly longer length of stay (9.1 vs. 6.6 days, p ?=?0.001), duration of nil per os (4.9 vs. 3.7 days, p ?=?0.007), and higher rates of complications, including systemic inflammatory response syndrome (81.5% vs. 44.6%, p ?=?0.001) and persistent acute kidney injury (25.9% vs. 3.6%, p ? p ?=?0.019). Conclusion NLR represents an inexpensive, readily available test with a promising value to predict disease severity in HTG-AP. Among the three inflammatory biomarkers, NLR has the highest discriminatory capacity for severe HTG-AP, with an optimal cut-off value of 10.