Obstructive sleep apnea intensifies stroke severity following middle cerebral artery occlusion

摘要

Study objectives: Obstructive sleep apnea (OSA) is a sleep disorder caused by transient obstruction of the upper airway and results in intermittent hypoxia, sleep fragmentation, sympathetic nervous system activation, and arousal which can have an adverse effect on cardiovascular disease. It is theorized that OSA might intensify stroke injury. Our goal here was to develop a new model of experimental OSA and test its ability to aggravate behavioral andmorphological outcomes following transient brain ischemia/reperfusion.