Influences of obstructive sleep apnea on blood pressure variability might not be limited only nocturnally in middle-aged hypertensive males

摘要

Purpose In this cross-sectional study, we analyzed the potential association between sleep measures and blood pressure variability. Methods Ninety-three middle-aged hypertensive males, who underwent polysomnography and 24-h ambulatory blood pressure monitoring, were enrolled. Blood pressure variability was assessed by blood pressure standard deviation. Obstructive sleep apnea (apnea hypopnea index ≥?15) was diagnosed in 52 (55.91%) patients. Mean body mass index and age were 27.77?±?3.11?kg/m_(2)and 44.05?±?8.07?years, respectively. Results Hypertensive males with obstructive sleep apnea showed significantly higher 24-h, diurnal, and nocturnal diastolic blood pressure variability, compared to those without obstructive sleep apnea. While total cohort was further divided into two groups using the median of oxygen desaturation index, another indicator for severity of OSA, significant differences were also observed in 24-h, diurnal, and nocturnal diastolic blood pressure variability between two groups with higher and lower oxygen desaturation index. While subjects were also divided into two groups via the mean of sleep stage 1, hypertensive males with sleep stage 1 ≥?8.1% showed significantly higher diurnal diastolic blood pressure variability than those with sleep stage 1