Pregnancies alters spine number in cortical and subcortical limbic brain regions of old rats

Flores‐Vivaldo Yaredit Margarita; Camacho‐Abrego Israel; Picazo Ofir; Flores Gonzalo

摘要

Abstract >Pregnancy is a complex process, involving a number of hormones and trophic factors, many of which are formed in the placenta. Several of these trophic factors have an effect at the neuronal level, such as BDNF. Consequently, recent reports have shown that exposure to these hormones (estrogen and progesterone) and trophic factors such as BDNF exert a neuroprotective effect. Here, we study the effect of the number of pregnancies on dendritic morphology of aged female rats (18?months of age). Rats of the 18‐month‐old Sprague Dawley strain with zero, one, two, and three gestations were evaluated for locomotor activity, and Golgi–Cox stain was performed to evaluate the dendritic morphology parameters, the number of dendritic spines, total dendritic length, and branching order number. Adult nulliparous rats (3?months of age) were used as another control group. Adult nulliparous and aging rats with two pregnancies showed an increase in locomotor activity. Adult nulliparous showed an increase in the dendritic spine number compared to old nulliparous rats in both layers of the PFC, the DG, and NAcc. Old rats with two and three pregnancies also showed an increase in the number of dendritic spines compared to old nulliparous rats in layers 3 and 5 of the PFC and in the CA1. Aging animals with one pregnancy also showed an increase in dendritic length compared to old nulliparous rats in the CA1. Our results clearly suggest that two and three pregnancies increase the dendritic spines number in the PFC and CA1 of aged female rats. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><abstract type =“main”xml：id =“syn22100-abs-0001”xml：lang =“en”> <title type =“main”>抽象</ title> >怀孕是一个复杂的过程，涉及一个复杂的过程，涉及一个复杂的过程，涉及一个复杂的过程激素和营养因子的数量，其中许多形成在胎盘中。这些营养因素中的一些在神经元水平上具有效果，例如BDNF。因此，最近的报告表明，暴露于这些激素（雌激素和孕激素）和营养因素，例如BDNF发挥神经保护作用。在这里，我们研究了妊娠期妊娠的效果对女性大鼠树突形态（18个月）。为118个月的Sprague Dawley菌株的大鼠评估了零，一个，两个和三个妊娠，对运动活性进行了评估，并且进行了戈尔基 - Cox染色以评估树突形态参数，树突状刺的数量，总树突长度和分支订单号。成年人无烟大鼠（3个月）用作另一种对照组。成年人无烟和老化大鼠有两只怀孕表现出运动量的增加。与PFC，DG和NACC两层中的旧无损伤大鼠相比，成年人无污染显示树突脊柱数量增加。与PFC层3和5中的旧无损伤大鼠相比，两三次妊娠的旧大鼠也显示出树枝状大鼠的数量增加。与一个妊娠的老化动物也表现出树枝状长度的增加，与CA1中的旧无污染大鼠相比。我们的结果清楚地表明，二和三次怀孕增加了老年女性大鼠PFC和Ca1中的树突刺。</ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-28762/'>《Synapse》</a> <b style="margin: 0 2px;">|</b><span>2019年第8期</span><b style="margin: 0 2px;">|</b><span>共12页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Flores‐Vivaldo Yaredit Margarita&option=202" target="_blank" rel="nofollow">Flores‐Vivaldo Yaredit Margarita;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Camacho‐Abrego Israel&option=202" target="_blank" rel="nofollow">Camacho‐Abrego Israel;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Picazo Ofir&option=202" target="_blank" rel="nofollow">Picazo Ofir;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Flores Gonzalo&option=202" target="_blank" rel="nofollow">Flores Gonzalo;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Laboratorio de Neuropsiquiatría Instituto de FisiologíaBenemérita Universidad Autónoma de PueblaPuebla Mexico;</p> <p>Laboratorio de Neuropsiquiatría Instituto de FisiologíaBenemérita Universidad Autónoma de PueblaPuebla Mexico;</p> <p>Escuela Superior de Medicina Instituto Politécnico NacionalMexico City Mexico;</p> <p>Laboratorio de Neuropsiquiatría Instituto de FisiologíaBenemérita Universidad Autónoma de PueblaPuebla Mexico;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/200.html" title="神经病学与精神病学">神经病学与精神病学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=aging&option=203" rel="nofollow">aging;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=female rats&option=203" rel="nofollow">female rats;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=hippocampus&option=203" rel="nofollow">hippocampus;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=prefrontal cortex&option=203" rel="nofollow">prefrontal cortex;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=pregnancies&option=203" rel="nofollow">pregnancies;</a> </p> <div class="translation"> 机译：衰老;女性大鼠;海马;前额外皮层;怀孕; </div> </li> </ul> </div> </div> <div class="literature cardcommon" id="literaturereference" style="display:none"> <div class="similarity "> <h3 class="all_title" id="enpatent111">引文网络</h3> <div class="referencetab clearfix"> <ul id="referencedaohang"> <li dataid="referenceul">参考文献</li> <li dataid="citationul">引证文献</li> <li dataid="commonreferenceul">共引文献</li> <li dataid="commoncitationul">同被引文献</li> <li dataid="tworeferenceul">二级参考文献</li> <li dataid="twocitationul">二级引证文献</li> </ul> </div> <div class="reference_details" id="referenceList"> <ul id="referenceul"></ul> <ul id="citationul"></ul> <ul id="commonreferenceul"></ul> <ul id="commoncitationul"></ul> <ul id="tworeferenceul"></ul> <ul id="twocitationul"></ul> </div> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704024355514.html">Pregnancies alters spine number in cortical and subcortical limbic brain regions of old rats</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Flores‐Vivaldo Yaredit Margarita&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Flores‐Vivaldo Yaredit Margarita,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Camacho‐Abrego Israel&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Camacho‐Abrego Israel,</a> <a 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<b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_detail_thesis/0201296790195.html">胚基底前脑和胚大脑皮质植入老年性痴呆模型鼠大脑皮质的研究</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=施碧涛&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 施碧涛</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=武义鸣&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,武义鸣</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=徐慧君&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,徐慧君</a> <span> <a href="/journal-cn-57286/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 立体定向和功能性神经外科杂志 </a> </span> <span> . 1990</span><span>,第4期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-27460_thesis/020221831876.html">小鼠大脑新皮质锥体神经元的新来源——大脑皮质套层</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=武胜昔&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 武胜昔</a> <span> <a href="/conference-cn-27460/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 第三届海内外华人中青年学者神经科学研讨会 </a> <span> <span> . 2004</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020311464463.html">CPZ诱导的精神分裂症样小鼠大脑皮质体积、皮质内有髓神经纤维及髓鞘改变的体视学研究</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=彭超&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 彭超</a> <span> . 2013</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120112043502.html">一种将神经束与大脑灰质连接终点投影在大脑皮质的方法</a> <b>[P]</b> . <span> 中国专利： CN112037210A </span> <span> . 2020-12-04</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120112047019.html">脊柱全皮质骨螺纹变径螺钉及脊柱定位定向装置</a> <b>[P]</b> . <span> 中国专利： CN112022317A </span> <span> . 2020-12-04</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130407182394.html">METHOD AND APPARATUS FOR COMPUTER MODELING OF THE INTERACTION BETWEEN AND AMONG CORTICAL AND SUBCORTICAL AREAS IN THE HUMAN BRAIN FOR THE PURPOSE OF PREDICTING THE EFFECT OF DRUGS IN PSYCHIATRIC AND COGNITIVE DISEASES</a> <b>[P]</b> . <span> 外国专利：  US2017372030A9 </span> <span> . 2017-12-28</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：目的在于预测药物在精神病性和认知性疾病中的作用的方法和装置，用于计算机模拟人体中的皮质和皮层下区域之间的相互作用 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130412663894.html">METHOD AND APPARATUS FOR COMPUTER MODELING OF THE INTERACTION BETWEEN AND AMONG CORTICAL AND SUBCORTICAL AREAS IN THE HUMAN BRAIN FOR THE PURPOSE OF PREDICTING THE EFFECT OF DRUGS IN PSYCHIATRIC AND COGNITIVE DISEASES</a> <b>[P]</b> . <span> 外国专利：  US2016224755A1 </span> <span> . 2016-08-04</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：目的在于预测药物在精神病性和认知性疾病中的作用的方法和装置，用于计算机模拟人体中的皮质和皮层下区域之间的相互作用 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130423046294.html">Method and apparatus for computer modeling of the interaction between and among cortical and subcortical areas in the human brain for the purpose of predicting the effect of drugs in psychiatric and cognitive diseases</a> <b>[P]</b> . <span> 外国专利：  US8150629B2 </span> <span> . 2012-04-03</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> 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