Zarxio (Filgrastim-sndz): The First Biosimilar Approved by the FDA

摘要

INTRODUCTION: Leukocytes are the body's main defense against infection. The most abundant leukocytes are neutrophils, also called granulocytes, which are important in fighting various microorganisms. Therefore, a decline in neutrophils-a condition called neutropenia-may predispose an individual to a host of illnesses. Absolute neutrophil count (ANC) is generally used to grade the severity of neutropenia, although there is no standard classification system. Neutropenia is defined as an ANC of less than 1.5 × 10~9/L, and its presentation may be mild (1-1.5 × 10~9/L), moderate (0.5-0.99 × 10~9/L), or severe (less than 0.5 × 10~9/L). In addition, neutropenia can be acute (occurring over hours to a few days) or chronic (lasting months to years).