Shorter preoperative fibrin clot lysis time predisposes to higher chest tube drainage in patients undergoing elective coronary artery bypass grafting surgery.

摘要

Postoperative bleeding following coronary artery bypass grafting surgery is associated with an increased rate of adverse events. Clot properties are essential for vessel integrity particularly at the sites of injury. To our knowledge, there have been no data on potential associations between intrinsic fibrin clot features and postoperative bleedings. We recruited 247 consecutive patients undergoing first-time, isolated, elective coronary artery bypass grafting surgery. Fibrin clot lysis time was measured in citrated plasma using a tissue factor-induced lysis assay. Although fibrinogen levels were similar in both extreme quintiles, clot lysis time was significantly shorter in patients in whom mediastinal drainage volume was in the highest quintile (P= 0.002). There were no differences in in-hospital major adverse events among the quintiles.