CATALYTIC, ENANTIOSELECTIVE, C-H FUNCTIONALIZATION TO FORM CARBON-CARBON BONDS

摘要

Traditional strategies toward enantioselective carbon-carbon (C-C) bond formation entail a functional-group transformation of either a heteroatom or an unsaturated bond.1-3 For example, transition-metal-catalyzed cross-coupling reactions are among the most powerful tools for C-C bond formation and, as such, are frequently used in synthesis. Although the past decades have witnessed remarkable advances in new ligands and catalysts for cross-coupling reactions, this reaction class is not without limitations.