Language comprehension and neurocognition independently and concurrently contribute to formal thought disorder severity in schizophrenia

摘要

Formal thought disorder (MD) in schizophrenia is a prevalent symptom that has a significant impact on patients but low remediation options. This is largely due to a still unclear aetiology, where both neurocognitive and language dysfunction have been shown to contribute. Given established relationships between neurocognition and language themselves, this study aimed to examine if language comprehension impairments have a significant effect on FTD severity independent of neurocognition. 54 schizophrenia/schizoaffective disorder patients (M 43.35, SD = 10.74) completed three measures of language comprehension along with the MATRICS Consensus Cognitive Battery and the D-KEFS Colour Word Interference Test. Symptomatology was assessed using the Positive and Negative Symptom Scale and the Scale for the Assessment of Thought, Language and Communication. Hierarchical linear regression analyses revealed syntactic sentence processing had a significant, and independent, contribution to positive FTD severity above neurocognition, while semantic sentence processing and single word semantic processing did not. The findings support the existence of a specific relationship between language comprehension dysfunction and FTD; however the question of generalisation to all aspects of language processing or FTD types needs further investigation. The establishment of a specific language-related impairment in schizophrenia which contributes independently to FTD severity supports the benefit of language-based remediation approaches for alleviating no symptoms and their effects. Clinical, aetiological and nosological implications of the results are discussed. (C) 2018 Elsevier B.V. All rights reserved.