Effect of punicalagin nanofibrous dressing on hydroxyproline during skin wound healing in adult Wistar rats.

摘要

Punicalagin with nanofibers of polyvinyl alcohol was produced by electrospinning and examined by scanning electron microscopy (SEM). Following routine surgical preparation, a 3cm circle of dorsal cervical skin was excised from groups of 10 rats each.Treated rats were given nanofiber with punicalagin daily for 7 consecutive days and controls were given nanofiber but without punicalagin. At 7 and 20 days later, rats were euthanized and biopsies were taken to determine hydroxyproline content. Rats treated punicalagin showed significant increases in hydroxyproline content by 7 days (1.41 ±0.111 mug/mg tissue) compared with controls (1.05 ±0.140 mug/mg tissue). These results suggest that treatment with punicalagin nanofibers may have increase collagenbiosynthesis in rat wounds.