A NEOFUNCTIONALIZED GENE ZCCHC5 IS EXPRESSED IN CARTILAGE AND ITS DOWNREGULATION INHIBITS COL2A1 EXPRESSION AND ENHANCES THE EXPRESSION OF MMP-13 IN CHONDROCYTES

Khan N. M.; Haqqi T. M.

首页> 外文期刊>Osteoarthritis and cartilage >A NEOFUNCTIONALIZED GENE ZCCHC5 IS EXPRESSED IN CARTILAGE AND ITS DOWNREGULATION INHIBITS COL2A1 EXPRESSION AND ENHANCES THE EXPRESSION OF MMP-13 IN CHONDROCYTES

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A NEOFUNCTIONALIZED GENE ZCCHC5 IS EXPRESSED IN CARTILAGE AND ITS DOWNREGULATION INHIBITS COL2A1 EXPRESSION AND ENHANCES THE EXPRESSION OF MMP-13 IN CHONDROCYTES

机译：一种新官能化基因ZCCHC5在软骨中表达，其下调抑制COL2A1表达并增强了软骨细胞中MMP-13的表达

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来源
《Osteoarthritis and cartilage》 |2018年第1期|共1页
作者
Khan N. M.; Haqqi T. M.;
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作者单位

Northeast Ohio Med Univ Rootstown OH USA;

Northeast Ohio Med Univ Rootstown OH USA;

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原文格式 PDF
正文语种 eng
中图分类骨科学（运动系疾病、矫形外科学）;
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1. A NEOFUNCTIONALIZED GENE ZCCHC5 IS EXPRESSED IN CARTILAGE AND ITS DOWNREGULATION INHIBITS COL2A1 EXPRESSION AND ENHANCES THE EXPRESSION OF MMP-13 IN CHONDROCYTES [J] . Khan N. M., Haqqi T. M. Osteoarthritis and cartilage . 2018,第Suppla1期

机译：一种新官能化基因ZCCHC5在软骨中表达，其下调抑制COL2A1表达并增强了软骨细胞中MMP-13的表达
2. NEOFUNCTIONALIZED GENE RTL3 AND SOX9 COLLECTIVELY MODULATE COL2A1 EXPRESSION IN HUMAN ARTICULAR CHONDROCYTES [J] . Osteoarthritis and cartilage . 2020,第Suppla1期

机译：新官能化基因RTL3和SOX9共同调节人关节软骨细胞中的COL2A1表达
3. The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases [J] . Jean-Pierre Pelletier, Christelle Boileau, Martin Boily, Arthritis Research . 2005,第5期

机译：立氟酮对实验性骨关节炎的保护作用与几种主要软骨分解代谢因子：MMP-13，组织蛋白酶K和软骨聚集蛋白聚糖酶的基因表达和蛋白质合成的下调相关
4. Down-regulated cathepsin K expression inhibit chondrocytes dedifferentiation and enhance cartilage formation in vivo [C] . Jie Li, Yan Zhang, Guangdong Zhou, World biomaterials congress . 2012

机译：组织蛋白酶K表达下调抑制软骨细胞去分化并增强体内软骨形成
5. Gene expression in phenotypically homogeneous chondrocytes from different articular cartilage layers of equine osteoarthritic and control joints: Method validation and gene array analysis. [D] . Dusterdieck, Katja Friederike. 2007

机译：在马骨关节炎和对照关节的不同关节软骨层的表型同质软骨细胞中的基因表达：方法验证和基因阵列分析。
6. The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13 cathepsin K and aggrecanases [O] . Jean-Pierre Pelletier, Christelle Boileau, Martin Boily, 2005

机译：力克酮对实验性骨关节炎的保护作用与几种主要软骨分解代谢因子：MMP-13组织蛋白酶K和软骨聚集蛋白聚糖酶的基因表达和蛋白质合成的下调相关
7. OP0259 Zcchc5, a ltr retrotransposon-derived neofunctionalized gene, is essential for the transcriptional activity of sox9 and the expression of col2a1 in chondrocytes and is downregulated in oa cartilage [O] . T.M. Haqqi, N.M. Khan 2018

机译：OP0259 ZCCHC5，LTR转回转化的新官能化基因对于SOX9的转录活性至关重要，以及在软骨细胞中的COL2A1的表达，并在OA软骨中下调

A NEOFUNCTIONALIZED GENE ZCCHC5 IS EXPRESSED IN CARTILAGE AND ITS DOWNREGULATION INHIBITS COL2A1 EXPRESSION AND ENHANCES THE EXPRESSION OF MMP-13 IN CHONDROCYTES

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