Metformin for Prevention of Hypertensive Disorders of Pregnancy in Women With Gestational Diabetes or Obesity: Systematic Review and Meta-analysis of Randomized Trials

摘要

Preeclampsia is a leading cause of maternal mortality and morbidity that imposes a substantial burden on the health care system. Metformin has been reported to reduce the risk of preeclampsia. It is also known to influence soluble fms-like tyrosine kinase 1 level, which correlates with the gestational age at onset and severity of preeclampsia. It has also been suggested that metformin may prevent preeclampsia by improving cardiovascular function and limiting gestational weight gain. Regardless of the underlying mechanism, the clinical implications are very important if metformin is proven effective in preventing late-onset preeclampsia.