二甲双胍治疗单纯性肥胖症疗效的系统评价

摘要

OBJECTIVE:Meta-analysis was carried out to systematically evaluate the efficacy of metforrnin in treatment of simple obesity.METHODS:Cochrane system evaluation was adopted,pertinent literatures published from 1994 to 2016 were retrieved from electronic literature database included Embase,Pubmed,HighWire Press,VIP,CBM,Wanfang,CNKI according to the key words of "Metformin,Simple obesity" or "Metformin in treatment of simple obesity".Literatures filtration and data extraction were conducted by two valuators,and literatures matched the criteria were analyzed by RevMan 5.1 software.RESULTS:A total of 10 studies involving 885 tested objects were included,with 439 cases in metformin treatment group,other 446 cases in control group,the follow-up period lasted 4-12 weeks.Meta-analysis showed the effect of monotherapy of metformin was not obvious in reducing body mass of patients with simple obesity compared with the control group(OR =0.37,95％ CI =0.18-0.77,Z =2.66,P ＜ 0.05).CONCLUSIONS:The efficacy of metformin in treatment of simple obesity is poor,which is not recommended for patients to lose weight.%目的:运用文献荟萃(Meta)分析法系统评价二甲双胍治疗单纯性肥胖症的疗效.方法:采用Cochrane系统评价方法,按检索策略,以“二甲双胍、单纯性肥胖症”或“二甲双胍治疗单纯性肥胖症”为关键词,在Embase、PubMed、HighWire Press、维普中文科技期刊数据库、中国生物医学文献数据库、万方数据库、中国知网数据库等电子文献数据库中检索1994-2016年发表的相关文献,由2名评价者对文献进行筛选和数据提取,对符合标准的文献采用RevMan 5.1软件进行Meta分析.结果:共纳入文献10篇,合计885例受试对象,其中二甲双胍治疗组439例,对照组446例,随访时间4 ～12周.Meta分析结果显示,与对照组比较,二甲双胍在降低单纯性肥胖症患者体质量方面的效果不明显(OR=0.37,95％CI=0.18 ～0.77,Z=2.66,P＜0.05).结论:二甲双胍对单纯性肥胖症的治疗效果差,不推荐用于单纯性肥胖症患者的减重.