Benefits and Risks of Antiretroviral Therapy for Perinatal HIV Prevention

摘要

Antiretroviral regimens used for the prevention of mother-to-child transmission of the human immunodeficiency virus (HIV) have evolved over the years. Combination antiretroviral therapy (ART) is currently used for prevention of motherto-child transmission of HIV but has shown more adverse effects compared with regimens containing fewer antiretroviral agents. This randomized trial evaluated the relative efficacy and safety of various proven antiretroviral strategies for prevention of mother-to-child transmission of HIV during pregnancy among asymptomatic HIV-infected women with high CD4 counts. All analyses were done on an intent-to-treat basis.