Vaginal Progesterone, Oral Progesterone, 17-OHPC, Cerclage, and Pessary for Preventing Preterm Birth in At-Risk Singleton Pregnancies: An Updated Systematic Review and Network Meta-analysis

摘要

Around the world, approximately 15 million pregnancies each year end in preterm birth (before 37 weeks' gestation), a major contributor to child morbidity and mortality. To reduce the risk of preterm birth for women at increased risk, interventions include progesterone, cervical cerclage, and cervical pessary. Previous studies concluded that progesterone (especially natural progesterone) was the best intervention to prevent preterm birth and neonatal death in women at risk and in women with a previous preterm birth. The researchers sought to update this meta-analysis comparing the 3 interventions' effectiveness in preventing pretermbirth at-risk women, women with a previous pretermbirth, and women with a short cervix, separating progesterone by administration.