Molecular Genetic Study of Association of the MTRR Gene A66G SNP with Dental Caries in Children with Congenital Cleft Lip and/or Palate and without Pathology

摘要

Association of the A66G SNP in the MTRR gene with dental caries was studied in children with congenital anomalies of the maxillofacial region (CA of MFR), i.e., with congenital cleft lip with or without cleft palate (CL, CP, and CLP) and in children without congenital anomalies. Comparison of samples of children with CL, CP, and CLP and children without congenital anomalies revealed association of the A66G SNP of the MTRR gene with the considered anomalies, which made it impossible to establish probable association of this marker with caries (for the G/G genotype, an association with the increased risk for developing CA of MFR was observed: OR = 2.16; P = 0.046; 95% CI (1.00-4.67). In children without pathology, an association of the A66G SNP of the MTRR gene with early caries was revealed. In carriers of the A/A genotype among children with primary and mixed bite (N = 91) and the mean age of 6.51 +/- 0.2 years, the risk for developing more severe form of caries was higher: OR = 4.91; P = 0.006; 95% CI (1.53-15.78); and among children with primary bite (N = 53) and the mean age of 4.71 +/- 0.18 years, OR = 10.53; P = 0.024; 95% CI (1.19-485.29). In children with heterozygous A/G genotype, the resistance to more severe form of caries was observed. Therefore, the A66G SNP of the MTRR gene can be considered as a marker of early caries in children without congenital anomalies.