Assessment of Adverse Drug Reaction Due to Cancer Chemotherapy in aTeaching Oncology Hospital in Isfahan, Central of Iran

摘要

Introduction: Adverse Drag Reactions (ADRs) are common in hospitalized oncology patients. The kinds ofADRs experienced by cancer patients are varied. Therefore, the identification of appropriate manner in order to preventADRs may improve patient outcome. Aims: The present study evaluated the incidence, frequency and common types of adverse drug reactions among hospital-ized oncology patients. Methods: Patients hospitalized at a university oncology center (children and adult) during the calendar year 2012 were ran-domly selected. Data were collected by reviewing of medical records. The outcome measures included the incidence of ob-served ADRs and ADR-related admissions and achieving strategies to prevent the emergence of chemotherapy side effects. Results: ADRs frequently occurred in the age group less than 20 years (22%). Prevalence of leukemia (27%), colon can-cer (16.5%) and breast cancer (14%) was higher in our region. Most ADRs were recorded in patients receiving cisplatin(44%), doxorubicin (24%) and 5-fluouracil (20%) as chemotherapy. The most frequently observed ADRs were nausea-vomiting, neutropenia and constipation in both pediatric and adult population. Conclusion: This study shows that ADRs occur more frequently in the pediatric group compared to adults. Therefore, op-timum use of preventative strategy program may contribute to reducing the incidence and severity of ADRs especially inthis group.