Evaluation of Anticancer Drug Utilization and Monitoring of Adverse Drug Reaction in the Indoor Patients Receiving Cancer Chemotherapy in a Tertiary Care Hospital in New Delhi

摘要

The main aim of drug utilization evaluation (DUE) is to promote the rational use of drugs in populations. The present study was designed to evaluate drug utilization pattern of anticancer drugs and to monitor the adverse drug reactions (ADR’s) in cancer patients receiving chemotherapy. Newly diagnosed patients of carcinoma which required treatment with chemotherapy, patients of both sex, and age18 years were included in the study. Cisplatin (20% patients) is the most commonly prescribed anti-cancer drug in this study followed by 5-Fluorouracil (16% patients). Average number of drugs per prescription was 9.18 and percentage of drugs prescribed from Essential Drugs List (EDL) was 93.5%. ADR’s were observed in 93% of the study patients. The most commonly implicated group of anticancer agents in ADR’s, was platinum analog (32%) followed by antimetabolites (22%) and taxanes (20%). Antimicrobial agents use was observed to be restricted and judicious.