Ovarian cancer is one of the most common gynaecologic cancers.Concerns pertaining to major health burden on society can be reduced by drug utilization study which gives an idea for detecting early signals of irrational drug use This cross-sectional observational study aims at analyzing utilization pattern of drugs and Adverse drug reactions in the treatment of ovarian cancer at a tertiary care hospital in perspective of standard treatment guidelines.170 patients of Ovarian Cancer receiving chemotherapy were enrolled in study after written informed consent of patients.Approval was obtained from institutional ethics committee.It was cross-sectional, observational study.Prescriptions were analysed for number of drugs prescribed using a predesigned format.Any Adverse Drug Reaction (ADR) observed by patient or treating physician was noted and causality was assessed by Naranjo’s algorithm.Preventability and severity of ADRs were assessed by modified Schumock and Thornton scale, modified Hartwig and Siegel scale respectively.In our study, ovarian cancer was encountered maximum in age group of 60-80 years.Most commonly prescribed chemotherapeutic drug was Paclitaxel (96.47%).Causality assessment of ADR by Naranjo’s algorithm showed 45.56% definite, 29.9% probable and 24.54% possible reactions.According to modified Schumock and Thornton scale, 30.73% reactions are ‘not preventable’, 5.36% are probably preventable, 63.91% are ‘definitely preventable’.According to modified Hartwig and Siegel scale, 51.96% were ‘mild’ severity however 48.04% were ‘moderate’ severity.
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