Association Between Hypothyroidism and Takotsubo Cardiomyopathy: Analysis of Nationwide Inpatient Sample Database

摘要

Background: Takotsubo Cardiomyopathy (TC), also called transient left ventricular (LV)ballooning syndrome, resembles myocardial infarction and is characterized by LV dysfunction in theabsence of coronary artery disease. Hypothesis described for TC has been an intense social stressor,pheochromocytoma, thyrotoxicosis among others. We performed this study to analyze the associationof hypothyroidism with TC.Methods: We queried the Nationwide Inpatient Sample which represents 20% of all the United Stateshospital data for our study. We identified TC and hypothyroidism through their respective ICD9.Codes for years 2006-2012. SAS 9.4 was used to perform a chi-square analysis to find any statisticalsignificance and p < 0.05 used to determine statistical significance. Significant differences were identifiedusing odds ratio (OR) estimates.Results: A total of 19,713 cases with TC were identified of which 17,340 (87.96%) were females and2,373 (12.04%) were males. 3,272 patients with TC had diagnosis of hypothyroidism. There is statisticallysignificant evidence of an association between TC and hypothyroidism (OR 2.21 (95% CI: 2.11-2.31); p<0.0001).There is evidence of increased statistical significance of females having TC 5.24 (95% CI: 4.96-5.53;(p<0.0001)) compared to males, with an increased statistically significance of females with hypothyroidismhaving TC, OR 6.65 (95% CI: 5.57-7.93; p< 0.001) compared to males.Conclusion: There is an increased association of hypothyroidism, especially hypothyroidism for femaleswith TC.