Isolation of high purity 73Se using solid phase extraction after selective 4,5-[73Se]benzopiazselenol formation with aminonaphthalene

摘要

A fast and efficient process for the production of the PET radionuclide 73Se was developed using 75Se as a surrogate. 75Se was separated from proton irradiated arsenic trioxide by reaction with 2,3-diaminonaphthalene to 4,5-[75Se]benzopiazelenol. This compound was purified using SPE column chromatography and subsequently decomposed with hydrogen peroxide. For further chemical conversions [75Se]selenite was reduced to elemental [75Se]selenium by either using thiosulfate or sulfur dioxide. The recovery yield of 75Se from the target amounted to 43%. The utility of the isolated 75Se for radiosyntheses was demonstrated by the successful preparation of [75Se]selenomethionine. The methodology developed using 75Se was successfully transformed to 73Se.