Convenient one-pot access to novel densely functionalized pyrano[2,3-d][1,3,4]thiadiazolo[3,2-a] pyrimidines via three component reaction

摘要

In this work, an efficient isocyanide-based three component method is developed for the synthesis of the novel substituted pyrano[2,3-d][1,3,4]thiadiazolo[3,2-a]pyrimidine system, having both the biologically active pyranopyrimidine and thiadiazolopyrimidine scaffolds, from the readily attainable reaction of 7-hydroxy-2-phenyl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidine-5-one, isocyanides, and dialkylacetylenedicarboxylates. This procedure has the chief advantages of fairly high reaction yields, mild reaction conditions, high atom-economy, and catalyst-free reaction.