Synthesis and Antimicrobial Activity of Some Sulfonamide Derivatives containing various Heterocyclic Moieties

摘要

A series of new sulfonamide derivatives derived from N-(4-acetylphenyl)-4-methylbenzenesulfonamide bearing different heterocyclic moieties such as 1,3-thiazole, 2-azetidinone and 4- thiazolidinone. The newly synthesized sulfhamide derivatives have been characterized by FTIR, 1H NMR, Mass spectra and elemental analysis. All the synthesized compounds were screened for their antimicrobial activity and compared with reference drug Amoxicillin. Heterocycleshave attracted thepresence of sulphonamide fragments in the attention of chemists because of their important biological properties and their role as pharmacofores [1-5]. Thiazole ring system has been consistently rewarded as alpromising molecule because of its broad spectrum of pharmaceutical activities like antimicrobial and anticancer [6-8]. Furthermore,derivaties containingSchifF base (azomethine) are a species of important compounds in medical chemistry and pharmacological field [9,10]. 2-Azetidinone have been found to be an important moiety in creation of novel medical drugs and they encompass pharmacological activities [11-14]. On the other hand, the 4-thiazolidinone scaffold is very versatile and has featured in a number of medicinal chemistry. They have found uses as antitubercular, antimicrobial and anticancer [13-15]. Tetrazole and their derivatives are found in many of the bioactive heterocyclic compounds that are of great interest due to various biological, and clinical applications [16,17].