Synthesis of Novel 3-(4-tert-Butylphenyl)-5-Cylopropyl-4H-1,2,4-Triazole Derivatives with Antioxidative and Antimicrobial Activities

Yildirim Nuri

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Synthesis of Novel 3-(4-tert-Butylphenyl)-5-Cylopropyl-4H-1,2,4-Triazole Derivatives with Antioxidative and Antimicrobial Activities

机译：具有抗氧化和抗微生物活性的新型3-（4-叔丁基苯基）-5-圆柱丙基-4H-1,2,4-三唑衍生物的合成

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Background: In this work, new heterocyclic compounds containing 3-(4-tert-butylphenyl)-5-cyclopropyl- 4H-1,2,4-triazole ring were synthesized, starting from iminoester hydrochlorides and 4-tert-butylbenzhyrazide.

机译：背景：在这项工作中，从亚丙基盐酸亚咪酯和4-叔丁基苯肼开始，合成了含有3-（4-叔丁基苯基）-5-环丙基-4H-1,2,4-三唑环的新的杂环化合物。

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《Letters in drug design & discovery》 |2020年第8期|共11页
作者
Yildirim Nuri;
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作者单位

Karadeniz Tech Univ Dept Chem Fac Sci Trabzon Turkey;

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原文格式 PDF
正文语种 eng
中图分类生药学（天然药物学）;
关键词
4H-1; 2; 4-triazoles; 4-arylmethyleneamino-4H-1; 2; 4-triazoles; Reactive oxygen species; phthalonitrile derivates; antioxidant; antimicrobial;

机译：4H-1;2;4-三唑;4-芳基甲基氨基-4H-1;2;4-三唑;反应性氧物种;酞酮衍生物;抗氧化剂;抗菌剂;抗菌剂;

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1. Synthesis of Novel 3-(4-tert-Butylphenyl)-5-Cylopropyl-4H-1,2,4-Triazole Derivatives with Antioxidative and Antimicrobial Activities [J] . Yildirim Nuri Letters in drug design & discovery . 2020,第8期

机译：具有抗氧化和抗微生物活性的新型3-（4-叔丁基苯基）-5-圆柱丙基-4H-1,2,4-三唑衍生物的合成
2. Synthesis and antimicrobial activity of 4-phenyl/cyclohexyl-5-(1-phenoxyethyl)-3-(N-(2-thiazolyl)acetamido)thio-4H -1,2,4-triazole derivatives. [J] . Turan Zitouni G, Yildiz MT, Kaya D European Journal of Medicinal Chemistry: Chimie Therapeutique . 2005,第6期

机译：4-苯基/环己基-5-（1-苯氧基乙基）-3-（N-（2-噻唑基）乙酰胺基）硫代-4H -1,2,4-三唑衍生物的合成及抗菌活性。
3. Synthesis of some new 1,2,4-triazole derivatives starting from 3-(4-Chlorophenyl)-5-(4-methoxybenzyl)-4H-1,2,4-triazol with anti-lipase and anti-urease activities [J] . BekircanO., Mente?eE., ülkerS., Archiv der Pharmazie . 2014,第6期

机译：由3-（4-氯苯基）-5-（4-甲氧基苄基）-4H-1,2,4-三唑起始的一些新的1,2,4-三唑衍生物的合成具有抗脂肪酶和抗脲酶活性
4. MICROWAVE ASSISTED SYNTHESIS OF SOME NEW 3-(4-AMINO-5-THIOXO-1,2,4-TRIAZOLE-3-YL)METHYL-2(3H)-BENZOXAZOLONE DERIVATIVES AS ANTIMICROBIAL AGENTS [C] . Solen URLU, Tijen ONKOL, M. Fethi SAHIN European Symposium on Organic Chemistry . 2009

机译：微波辅助合成一些新的3 - （4-氨基-5-硫代-1,2,4-三唑-3-基）甲基 -2（3H） - 低恶唑酮衍生物作为抗微生物剂
5. I. A1,3- strain enabled retention of chirality during Bis-cyclization of β-ketoamides: Asymmetric synthesis and bioactivity of salinosporamide a and derivatives II. Optimization of an Organic syntheses procedure: asymmetric nucleophile-catalyzed aldol-lactonization with aldehyde acids [D] . Nguyen, Henry 2010

机译：I. A1,3-菌株能够在β-酮基酰胺的双环化过程中保留手性：salinosporamide a和衍生物II的不对称合成和生物活性。有机合成程序的优化：醛酸不对称亲核催化醛醇内酯化
6. Antimicrobial activity of thiophene derivatives derived from ethyl (E)-5-(3-(dimethylamino)acryloyl)-4-methyl-2-(phenylamino)thiophene-3-carboxylate [O] . Yahia Nasser Mabkhot, Nahed Ahmed Kaal, Seham Alterary, 2017

机译：（E）-5-（3-（二甲基氨基）丙烯酰基）-4-甲基-2-（苯基氨基）噻吩-3-羧酸乙酯衍生的噻吩衍生物的抗菌活性
7. Synthesis and antimicrobial activity of 3,5-R-4-(3-(5-nitrofuran-2-yl)-allylidenamino)-1-R1-4H-1,2,4-triazole halides derivatives [O] . T. S. Brytanova, A. S. Gotsulya, O. I. Panasenko, 2015

机译：3,5-R-4-（3-（5-硝基呋喃-2-基）-1-R1-4H-1,2,4-三唑卤化物衍生物的合成和抗微生物活性
8. Synthesis and Biological Activity of Substituted Urea and Thiourea Derivatives Containing 1,2,4-Triazole Moieties. [R] . Kocyigit-Kaymakcioglu, B., Celen, A. O., Tabanca, N., 2013

机译：含1,2,4-三唑部分的取代脲和硫脲衍生物的合成及生物活性。

Synthesis of Novel 3-(4-tert-Butylphenyl)-5-Cylopropyl-4H-1,2,4-Triazole Derivatives with Antioxidative and Antimicrobial Activities

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