The Identification of New CD38 Inhibitors by Combined Structure and Ligand Based Virtual Screening Approaches of ZINC Database

摘要

Background: Cluster of differentiation 38 (CD38) is major NADase and regulates the intracellular level of NAD. It uses NAD as substrate to produce ADP Ribose (ADPR) and cyclic ADP ribose (cADPR) and converts NADP to NAADP. Its inhibition can be utilized to treat several condition.