Searching for Potential HDAC2 Inhibitors: Structure-activity Relationship Studies on Indole-based Hydroxamic Acids as an Anticancer Agent

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Searching for Potential HDAC2 Inhibitors: Structure-activity Relationship Studies on Indole-based Hydroxamic Acids as an Anticancer Agent

机译：寻找潜在的HDAC2抑制剂：结构 - 活性关系研究吲哚基羟肟酸作为抗癌剂

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Aim: To predict the most potent indole based HDAC2 inhibitors from several scientific reports through the process of lead identification and SAR development.

机译：目的：通过铅鉴定和SAR发展的过程预测来自几个科学报告的最有效的吲哚2抑制剂。

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《Letters in drug design & discovery》 |2020年第7期|共13页
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正文语种 eng
中图分类生药学（天然药物学）;
关键词
Hydroxamate; HDAC inhibitors; pharmacophore; 3D QSAR; docking studies; anticancer agents;

机译：羟肟酸盐;HDAC抑制剂;Pharmacophore;3D QSAR;对接研究;抗癌剂;

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专利

1. Searching for Potential HDAC2 Inhibitors: Structure-activity Relationship Studies on Indole-based Hydroxamic Acids as an Anticancer Agent [J] . Letters in drug design & discovery . 2020,第7期

机译：寻找潜在的HDAC2抑制剂：结构 - 活性关系研究吲哚基羟肟酸作为抗癌剂
2. Synthesis, structure-activity relationship and molecular docking studies of novel quinoline-chalcone hybrids as potential anticancer agents and tubulin inhibitors [J] . Mirzaei Salimeh, Hadizadeh Farzin, Eisvand Farhad, Journal of Molecular Structure . 2020,第1期

机译：新型喹啉 - 螯合杂交物的合成，结构活性关系和分子对接研究作为潜在的抗癌剂和微管蛋白抑制剂
3. Synthesis, structure-activity relationship and biological evaluation of novel nitrogen mustard sophoridinic acid derivatives as potential anticancer agents [J] . Li Dong-Dong, Dai Lin-Lin, Zhang Na, Bioorganic and Medicinal Chemistry Letters . 2015,第19期

机译：新型氮芥芥基槐二酸衍生物作为潜在抗癌剂的合成，构效关系及生物学评价
4. DFT studies on the quantitative structure-activity relationship of N-(2-chloroethyl)-N′-cyclohexyl-N-nitrosoureas as anticancer agents [C] . Cao Jun, Jin Shubin, Han Bing, 2010 3rd International Conference on Biomedical Engineering and Informatics . 2010

机译：DFT研究N-（2-氯乙基）-N'-环己基-N-亚硝基脲作为抗癌剂的定量构效关系
5. A structure-activity approach to drug action in pharmacology: (A) Structure-activity relationships involved in DT-diaphorase (NQO1) mediated reduction kinetics and mode of action of anticancer bioreductive benzoquinone alkylating agents. (B) Structural characteristics of novel NMDA receptor antagonists required for renal tubule organic cation secretion . [D] . Fourie, Jeanne. 2004

机译：一种在药理学中用于药物作用的结构活性方法：（A）DT-黄递酶（NQO1）介导的抗癌生物还原苯醌烷基化剂的还原动力学和作用方式的结构活性关系。（B）肾小管有机阳离子分泌所需的新型NMDA受体拮抗剂的结构特征。
6. Azaindenoisoquinolines as Topoisomerase I Inhibitors and Potential Anticancer Agents: A Systematic Study of Structure-Activity Relationships [O] . Evgeny Kiselev, Keli Agama, Yves Pommier, -1

机译：azaindenoisoquinolines如拓扑异构酶I抑制剂和潜在的抗癌药物：构效关系的系统研究
7. In silco studies on modified hydroxamic acid and valporic acid as potential inhibitors for HDAC2 [O] . Naresh Kandakatla, Shikha Rathaur, Smruti Sandhya Sahoo, 2013

机译：在改良的异羟肟酸和valporic acid作为HDaC2的潜在抑制剂的silco研究中

Searching for Potential HDAC2 Inhibitors: Structure-activity Relationship Studies on Indole-based Hydroxamic Acids as an Anticancer Agent

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