The synthesis of imidazoles and evaluation of their antioxidant and antifungal activities

摘要

Tri- and tetra-substituted imidazole compounds were synthesized through in situ oxidation-condensation in the presence of catalytic amount of H(2)PW(12)O(40)A loaded on the ionic liquid-functionalized magnetic nanoparticles. Then, the antioxidant and antifungal activities of the new imidazoles were evaluated. The effectiveness of the samples as DPPH radical scavengers was confirmed by the measured IC50 values and thiophenyl-containing product showed the best IC50 of 0.12 when compared to the standard ascorbic acid. Moreover, all compounds have antifungal activity against Fusarium oxysporum.